Abstract
The cytogenetic analysis of a well-differentiated (grade I) chondrosarcoma is presented. Despite a low-grade histopathology, metaphase preparations of tumor cells were characterized by numerous structural chromosome aberrations and a striking degree of genetic instability; the t(9;22)(q31;q12) that has been described recently in extraskeletal myxoid chondrosarcoma was not observed. This report suggests that chondrosarcomas may be heterogeneous cytogenetically. In chondrosarcoma, it appears that "high-grade" cytogenetic abnormalities do not necessarily engender a high-grade histology. These findings offer a possible explanation for the clinical aggressiveness of certain low-grade chondrosarcomas.
| Original language | English |
|---|---|
| Pages (from-to) | 115-21 |
| Number of pages | 7 |
| Journal | Cancer Genetics and Cytogenetics |
| Volume | 41 |
| Issue number | 1 |
| Publication status | Published - Aug 1989 |
Keywords
- Aged
- Chondrosarcoma
- Chromosome Aberrations
- Chromosome Banding
- Genetic Markers
- Humans
- Karyotyping
- Male
- Pelvic Neoplasms
- Case Reports
- Journal Article