Projects per year
Abstract
Biogenic waste-derived feedstocks for production of fuels, chemicals, and materials offer great potential supporting the transition to net-zero and greater circularity. However, such feedstocks are heterogeneous and subject to geographical and seasonal variability. Here, we show that, through careful strain selection and metabolic engineering, Pseudomonas putida can be employed to permit efficient co-utilization of highly heterogeneous substrate compositions derived from hydrolyzed mixed municipal-like waste fractions (food, plastic, organic, paper, cardboard, and textiles) for growth and synthesis of exemplar bioproducts. Design of experiments was employed to explore the combinatorial space of nine waste-derived monomers, displaying robust catabolic efficiency regardless of substrate composition. Prospective Life-Cycle Assessment (LCA) and Life-Cycle Costing (LCC) illustrated the climate change (CC) and economic advantages of biomanufacturing compared with conventional waste treatment options, demonstrating a 41–62% potential reduction in CC impact. This work demonstrates the potential for expanding treatment strategies for mixed waste to include engineered microbes.
Original language | English |
---|---|
Journal | Trends in Biotechnology |
Early online date | 4 Dec 2024 |
DOIs | |
Publication status | E-pub ahead of print - 4 Dec 2024 |
Keywords
- MSW valorisation
- land-use negative feedstock
- Pseudomonas putida
- biopolymers
- waste-to-wealth
Fingerprint
Dive into the research topics of 'Complex waste stream valorisation through combined enzymatic hydrolysis and catabolic assimilation by Pseudomonas putida'. Together they form a unique fingerprint.Projects
- 1 Finished
-
Lignin Valorization in Cellulosic Ethanol Plants: Biocatalytic Conversion via Ferulic Acid to High Value Chemicals
Dixon, N. (PI) & Turner, N. (CoI)
1/01/17 → 31/12/22
Project: Research