Comprehensive assessment of rheumatoid arthritis susceptibility loci in a large psoriatic arthritis cohort.

John Bowes; Pauline Ho; Edward Flynn; Faisal Ali; Helena Marzo-Ortega; Laura C Coates; Richard B Warren; Ross McManus; Anthony W Ryan; David Kane; Eleanor Korendowych; Neil McHugh; Oliver FitzGerald; Jonathon Packham; Ann W Morgan; Ian N Bruce; Anne Barton

doi:10.1136/annrheumdis-2011-200802

Comprehensive assessment of rheumatoid arthritis susceptibility loci in a large psoriatic arthritis cohort.

John Bowes, Pauline Ho, Edward Flynn, Faisal Ali, Helena Marzo-Ortega, Laura C Coates, Richard B Warren, Ross McManus, Anthony W Ryan, David Kane, Eleanor Korendowych, Neil McHugh, Oliver FitzGerald, Jonathon Packham, Ann W Morgan, Ian N Bruce, Anne Barton

Research output: Contribution to journal › Article › peer-review

Abstract

OBJECTIVE: A number of rheumatoid arthritis (RA) susceptibility genes have been identified in recent years. Given the overlap in phenotypic expression of synovial joint inflammation between RA and psoriatic arthritis (PsA), the authors explored whether RA susceptibility genes are also associated with PsA. METHODS: 56 single nucleotide polymorphisms (SNPs) mapping to 41 genes previously reported as RA susceptibility loci were selected for investigation. PsA was defined as an inflammatory arthritis associated with psoriasis and subjects were recruited from the UK and Ireland. Genotyping was performed using the Sequenom MassArray platform and frequencies compared with data derived from large UK control collections. RESULTS: Significant evidence for association with susceptibility to PsA was found toa SNP mapping to the REL (rs13017599, p(trend)=5.2×10(4)) gene, while nominal evidence for association (p(trend)

Original language	English
Pages (from-to)	1350-1354
Number of pages	4
Journal	Annals of the rheumatic diseases
Volume	71
Issue number	8
DOIs	https://doi.org/10.1136/annrheumdis-2011-200802
Publication status	Published - Aug 2012

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Bowes, J., Ho, P., Flynn, E., Ali, F., Marzo-Ortega, H., Coates, L. C., Warren, R. B., McManus, R., Ryan, A. W., Kane, D., Korendowych, E., McHugh, N., FitzGerald, O., Packham, J., Morgan, A. W., Bruce, I. N., & Barton, A. (2012). Comprehensive assessment of rheumatoid arthritis susceptibility loci in a large psoriatic arthritis cohort. Annals of the rheumatic diseases, 71(8), 1350-1354. https://doi.org/10.1136/annrheumdis-2011-200802

@article{26cd6719de854cc18e532c222646029a,

title = "Comprehensive assessment of rheumatoid arthritis susceptibility loci in a large psoriatic arthritis cohort.",

abstract = "OBJECTIVE: A number of rheumatoid arthritis (RA) susceptibility genes have been identified in recent years. Given the overlap in phenotypic expression of synovial joint inflammation between RA and psoriatic arthritis (PsA), the authors explored whether RA susceptibility genes are also associated with PsA. METHODS: 56 single nucleotide polymorphisms (SNPs) mapping to 41 genes previously reported as RA susceptibility loci were selected for investigation. PsA was defined as an inflammatory arthritis associated with psoriasis and subjects were recruited from the UK and Ireland. Genotyping was performed using the Sequenom MassArray platform and frequencies compared with data derived from large UK control collections. RESULTS: Significant evidence for association with susceptibility to PsA was found toa SNP mapping to the REL (rs13017599, p(trend)=5.2×10(4)) gene, while nominal evidence for association (p(trend)",

author = "John Bowes and Pauline Ho and Edward Flynn and Faisal Ali and Helena Marzo-Ortega and Coates, {Laura C} and Warren, {Richard B} and Ross McManus and Ryan, {Anthony W} and David Kane and Eleanor Korendowych and Neil McHugh and Oliver FitzGerald and Jonathon Packham and Morgan, {Ann W} and Bruce, {Ian N} and Anne Barton",

note = "076113, Wellcome Trust, United Kingdom085475, Wellcome Trust, United Kingdom17552, Arthritis Research UK, United Kingdom17552, Arthritis Research UK, United Kingdom",

year = "2012",

month = aug,

doi = "10.1136/annrheumdis-2011-200802",

language = "English",

volume = "71",

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journal = "Annals of the rheumatic diseases",

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Bowes, J , Ho, P, Flynn, E, Ali, F, Marzo-Ortega, H, Coates, LC, Warren, RB, McManus, R, Ryan, AW, Kane, D, Korendowych, E, McHugh, N, FitzGerald, O, Packham, J, Morgan, AW, Bruce, IN & Barton, A 2012, 'Comprehensive assessment of rheumatoid arthritis susceptibility loci in a large psoriatic arthritis cohort.', Annals of the rheumatic diseases, vol. 71, no. 8, pp. 1350-1354. https://doi.org/10.1136/annrheumdis-2011-200802

TY - JOUR

T1 - Comprehensive assessment of rheumatoid arthritis susceptibility loci in a large psoriatic arthritis cohort.

AU - Bowes, John

AU - Ho, Pauline

AU - Flynn, Edward

AU - Ali, Faisal

AU - Marzo-Ortega, Helena

AU - Coates, Laura C

AU - Warren, Richard B

AU - McManus, Ross

AU - Ryan, Anthony W

AU - Kane, David

AU - Korendowych, Eleanor

AU - McHugh, Neil

AU - FitzGerald, Oliver

AU - Packham, Jonathon

AU - Morgan, Ann W

AU - Bruce, Ian N

AU - Barton, Anne

N1 - 076113, Wellcome Trust, United Kingdom085475, Wellcome Trust, United Kingdom17552, Arthritis Research UK, United Kingdom17552, Arthritis Research UK, United Kingdom

PY - 2012/8

Y1 - 2012/8

N2 - OBJECTIVE: A number of rheumatoid arthritis (RA) susceptibility genes have been identified in recent years. Given the overlap in phenotypic expression of synovial joint inflammation between RA and psoriatic arthritis (PsA), the authors explored whether RA susceptibility genes are also associated with PsA. METHODS: 56 single nucleotide polymorphisms (SNPs) mapping to 41 genes previously reported as RA susceptibility loci were selected for investigation. PsA was defined as an inflammatory arthritis associated with psoriasis and subjects were recruited from the UK and Ireland. Genotyping was performed using the Sequenom MassArray platform and frequencies compared with data derived from large UK control collections. RESULTS: Significant evidence for association with susceptibility to PsA was found toa SNP mapping to the REL (rs13017599, p(trend)=5.2×10(4)) gene, while nominal evidence for association (p(trend)

AB - OBJECTIVE: A number of rheumatoid arthritis (RA) susceptibility genes have been identified in recent years. Given the overlap in phenotypic expression of synovial joint inflammation between RA and psoriatic arthritis (PsA), the authors explored whether RA susceptibility genes are also associated with PsA. METHODS: 56 single nucleotide polymorphisms (SNPs) mapping to 41 genes previously reported as RA susceptibility loci were selected for investigation. PsA was defined as an inflammatory arthritis associated with psoriasis and subjects were recruited from the UK and Ireland. Genotyping was performed using the Sequenom MassArray platform and frequencies compared with data derived from large UK control collections. RESULTS: Significant evidence for association with susceptibility to PsA was found toa SNP mapping to the REL (rs13017599, p(trend)=5.2×10(4)) gene, while nominal evidence for association (p(trend)

U2 - 10.1136/annrheumdis-2011-200802

DO - 10.1136/annrheumdis-2011-200802

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SN - 1468-2060

VL - 71

SP - 1350

EP - 1354

JO - Annals of the rheumatic diseases

JF - Annals of the rheumatic diseases

IS - 8

ER -

Comprehensive assessment of rheumatoid arthritis susceptibility loci in a large psoriatic arthritis cohort.

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