Concentration dependence of the osmotic and activity coefficients of imipramine and clomipramine hydrochlorides in aqueous solution

Pablo Taboada; David Attwood; Juan M. Ruso; María J. Suárez; Félix Sarmiento; Víctor Mosquera

doi:10.1021/je990060o

Concentration dependence of the osmotic and activity coefficients of imipramine and clomipramine hydrochlorides in aqueous solution

Pablo Taboada, David Attwood, Juan M. Ruso, María J. Suárez, Félix Sarmiento, Víctor Mosquera

Research output: Contribution to journal › Article › peer-review

Abstract

Vapor pressure lowering of the two antidepressant drugs imipramine and clomipramine hydrochloride solutions in the concentration range 0-0.28 mol·kg-1 at 303.15 K were determined. For imipramine hydrochloride, measurements at 308.15 and 313.15 K were also made. From these results, the osmotic and activity coefficients for both compounds were calculated, and their concentration dependence was studied. An inflection point was detected for each substance, identified as a critical concentration.

Original language	English
Pages (from-to)	820-822
Number of pages	2
Journal	Journal of Chemical and Engineering Data
Volume	44
Issue number	4
DOIs	https://doi.org/10.1021/je990060o
Publication status	Published - Jul 1999

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title = "Concentration dependence of the osmotic and activity coefficients of imipramine and clomipramine hydrochlorides in aqueous solution",

abstract = "Vapor pressure lowering of the two antidepressant drugs imipramine and clomipramine hydrochloride solutions in the concentration range 0-0.28 mol·kg-1 at 303.15 K were determined. For imipramine hydrochloride, measurements at 308.15 and 313.15 K were also made. From these results, the osmotic and activity coefficients for both compounds were calculated, and their concentration dependence was studied. An inflection point was detected for each substance, identified as a critical concentration.",

author = "Pablo Taboada and David Attwood and Ruso, {Juan M.} and Su{\'a}rez, {Mar{\'i}a J.} and F{\'e}lix Sarmiento and V{\'i}ctor Mosquera",

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T1 - Concentration dependence of the osmotic and activity coefficients of imipramine and clomipramine hydrochlorides in aqueous solution

AU - Taboada, Pablo

AU - Attwood, David

AU - Ruso, Juan M.

AU - Suárez, María J.

AU - Sarmiento, Félix

AU - Mosquera, Víctor

PY - 1999/7

Y1 - 1999/7

N2 - Vapor pressure lowering of the two antidepressant drugs imipramine and clomipramine hydrochloride solutions in the concentration range 0-0.28 mol·kg-1 at 303.15 K were determined. For imipramine hydrochloride, measurements at 308.15 and 313.15 K were also made. From these results, the osmotic and activity coefficients for both compounds were calculated, and their concentration dependence was studied. An inflection point was detected for each substance, identified as a critical concentration.

AB - Vapor pressure lowering of the two antidepressant drugs imipramine and clomipramine hydrochloride solutions in the concentration range 0-0.28 mol·kg-1 at 303.15 K were determined. For imipramine hydrochloride, measurements at 308.15 and 313.15 K were also made. From these results, the osmotic and activity coefficients for both compounds were calculated, and their concentration dependence was studied. An inflection point was detected for each substance, identified as a critical concentration.

U2 - 10.1021/je990060o

DO - 10.1021/je990060o

M3 - Article

VL - 44

SP - 820

EP - 822

JO - Journal of Chemical and Engineering Data

JF - Journal of Chemical and Engineering Data

IS - 4

ER -

Concentration dependence of the osmotic and activity coefficients of imipramine and clomipramine hydrochlorides in aqueous solution

Abstract

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