Concerted activity of IgG1 antibodies and IL-4/IL-25-dependent effector cells trap helminth larvae in the tissues following vaccination with defined secreted antigens, providing sterile immunity to challenge infection.

JP Hewitson; KJ Filbey; Bieren J Esser-von; M Camberis; C Schwartz; J Murray; LA Reynolds; N Blair; E Robertson; Y Harcus; L Boon; SC Huang; L Yang; Yizheng Tu; Mark J.  Miller; David Voehringer; Graham Le Gros; Nicola L. Harris; RM Maizels

doi:10.1371/journal.ppat.1004676

Concerted activity of IgG1 antibodies and IL-4/IL-25-dependent effector cells trap helminth larvae in the tissues following vaccination with defined secreted antigens, providing sterile immunity to challenge infection.

JP Hewitson, KJ Filbey, Bieren J Esser-von, M Camberis, C Schwartz, J Murray, LA Reynolds, N Blair, E Robertson, Y Harcus, L Boon, SC Huang, L Yang, Yizheng Tu, Mark J. Miller, David Voehringer, Graham Le Gros, Nicola L. Harris, RM Maizels

Division of Immunology, Immunity to Infection and Respiratory Medicine

Research output: Contribution to journal › Article › peer-review

Original language	English
Journal	PLoS Pathogens
DOIs	https://doi.org/10.1371/journal.ppat.1004676
Publication status	Published - Mar 2015

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10.1371/journal.ppat.1004676

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Hewitson, JP., Filbey, KJ., Esser-von, B. J., Camberis, M., Schwartz, C., Murray, J., Reynolds, LA., Blair, N., Robertson, E., Harcus, Y., Boon, L., Huang, SC., Yang, L., Tu, Y., Miller, M. J., Voehringer, D., Gros, G. L., Harris, N. L., & Maizels, RM. (2015). Concerted activity of IgG1 antibodies and IL-4/IL-25-dependent effector cells trap helminth larvae in the tissues following vaccination with defined secreted antigens, providing sterile immunity to challenge infection. PLoS Pathogens. https://doi.org/10.1371/journal.ppat.1004676

@article{db10644ca8b84ea790304bdd1d888cf2,

title = "Concerted activity of IgG1 antibodies and IL-4/IL-25-dependent effector cells trap helminth larvae in the tissues following vaccination with defined secreted antigens, providing sterile immunity to challenge infection.",

author = "JP Hewitson and KJ Filbey and Esser-von, {Bieren J} and M Camberis and C Schwartz and J Murray and LA Reynolds and N Blair and E Robertson and Y Harcus and L Boon and SC Huang and L Yang and Yizheng Tu and Miller, {Mark J.} and David Voehringer and Gros, {Graham Le} and Harris, {Nicola L.} and RM Maizels",

year = "2015",

month = mar,

doi = "10.1371/journal.ppat.1004676",

language = "English",

journal = "PLoS Pathogens",

issn = "1553-7374",

publisher = "Public Library of Science",

}

Hewitson, JP, Filbey, KJ, Esser-von, BJ, Camberis, M, Schwartz, C, Murray, J, Reynolds, LA, Blair, N, Robertson, E, Harcus, Y, Boon, L, Huang, SC, Yang, L, Tu, Y, Miller, MJ, Voehringer, D, Gros, GL, Harris, NL & Maizels, RM 2015, 'Concerted activity of IgG1 antibodies and IL-4/IL-25-dependent effector cells trap helminth larvae in the tissues following vaccination with defined secreted antigens, providing sterile immunity to challenge infection.', PLoS Pathogens. https://doi.org/10.1371/journal.ppat.1004676

Concerted activity of IgG1 antibodies and IL-4/IL-25-dependent effector cells trap helminth larvae in the tissues following vaccination with defined secreted antigens, providing sterile immunity to challenge infection. / Hewitson, JP; Filbey, KJ; Esser-von, Bieren J et al.
In: PLoS Pathogens, 03.2015.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Concerted activity of IgG1 antibodies and IL-4/IL-25-dependent effector cells trap helminth larvae in the tissues following vaccination with defined secreted antigens, providing sterile immunity to challenge infection.

AU - Hewitson, JP

AU - Filbey, KJ

AU - Esser-von, Bieren J

AU - Camberis, M

AU - Schwartz, C

AU - Murray, J

AU - Reynolds, LA

AU - Blair, N

AU - Robertson, E

AU - Harcus, Y

AU - Boon, L

AU - Huang, SC

AU - Yang, L

AU - Tu, Yizheng

AU - Miller, Mark J.

AU - Voehringer, David

AU - Gros, Graham Le

AU - Harris, Nicola L.

AU - Maizels, RM

PY - 2015/3

Y1 - 2015/3

UR - http://europepmc.org/abstract/med/25816012

U2 - 10.1371/journal.ppat.1004676

DO - 10.1371/journal.ppat.1004676

M3 - Article

C2 - 25816012

SN - 1553-7374

JO - PLoS Pathogens

JF - PLoS Pathogens

ER -

Concerted activity of IgG1 antibodies and IL-4/IL-25-dependent effector cells trap helminth larvae in the tissues following vaccination with defined secreted antigens, providing sterile immunity to challenge infection.

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