Abstract
OBJECTIVE: Our purpose was to determine the frequency of confined placental mosaicism in newborns with unexplained intrauterine growth retardation compared with infants with appropriate in utero growth.
STUDY DESIGN: Amnion, chorion, and villi from 12 growth-retarded infants and 24 appropriately grown, matched controls were karyotyped. Fluorescence in situ hybridization with chromosome-specific probes was then used to confirm the karyotypic abnormality at additional uncultured placental sites.
RESULTS: Karyotype analysis revealed placental mosaicism involving either aneuploidy or polyploidy in three of 12 (25%) cases versus two of 24 (8.3%) controls. Fluorescence in situ hybridization confirmed the karyotypic abnormalities in the placentas from growth-retarded infants only.
CONCLUSION: Confined placental mosaicism was identified three times more frequently from placentas of growth-retarded infants compared with those of newborns with appropriate growth. Molecular studies of the placentas suggested a wider distribution of cells with abnormal karyotypes in cases compared with controls and support a biologic influence of placental mosaicism on fetal growth.
| Original language | English |
|---|---|
| Pages (from-to) | 44-50 |
| Number of pages | 7 |
| Journal | American Journal of Obstetrics and Gynecology |
| Volume | 172 |
| Issue number | 1 Pt 1 |
| Publication status | Published - Jan 1995 |
Keywords
- Amnion
- Case-Control Studies
- Chorion
- Chorionic Villi
- Female
- Fetal Growth Retardation
- Humans
- In Situ Hybridization, Fluorescence
- Infant, Newborn
- Karyotyping
- Mosaicism
- Placenta
- Ploidies
- Pregnancy
- Reference Values
- Journal Article
- Research Support, Non-U.S. Gov't