Congestive heart failure: experimental model.

Antonio Francesco Corno, Xue Cai, Caroline B Jones, Giuseppina Mondani, Mark R Boyett, Jonathan Charles Jarvis, George Hart

    Research output: Contribution to journalArticlepeer-review


    INTRODUCTION: Surgically induced, combined volume and pressure overload has been used in rabbits to create a simplified and reproducible model of acute left ventricular (LV) failure. MATERIALS AND METHODS: New Zealand white male rabbits (n = 24, mean weight 3.1 ± 0.2 kg) were randomly assigned to either the Control group (n = 10) or to the Heart Failure group (HF, n = 14). Animals in the Control group underwent "sham" procedures. Animals in the HF group underwent procedures to induce LV volume overload by inducing severe aortic valve regurgitation with aortic cusp disruption and pressure overload using an occlusive silver clip positioned around the pre-renal abdominal aorta. RESULTS: Following Procedure-1 (volume overload) echocardiography confirmed severe aortic regurgitation in all animals in the HF group, with increased mean pulse pressure difference from 18 ± 3 to 38 ± 3 mmHg (P 
    Original languageEnglish
    JournalFrontiers in pediatrics
    Publication statusPublished - 2013


    • congestive heart failure
    • experimental research
    • left heart failure
    • ventricular dilatation
    • ventricular hyprtrophy


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