TY - JOUR
T1 - Congestive heart failure: experimental model.
AU - Corno, Antonio Francesco
AU - Cai, Xue
AU - Jones, Caroline B
AU - Mondani, Giuseppina
AU - Boyett, Mark R
AU - Jarvis, Jonathan Charles
AU - Hart, George
PY - 2013
Y1 - 2013
N2 - INTRODUCTION: Surgically induced, combined volume and pressure overload has been used in rabbits to create a simplified and reproducible model of acute left ventricular (LV) failure. MATERIALS AND METHODS: New Zealand white male rabbits (n = 24, mean weight 3.1 ± 0.2 kg) were randomly assigned to either the Control group (n = 10) or to the Heart Failure group (HF, n = 14). Animals in the Control group underwent "sham" procedures. Animals in the HF group underwent procedures to induce LV volume overload by inducing severe aortic valve regurgitation with aortic cusp disruption and pressure overload using an occlusive silver clip positioned around the pre-renal abdominal aorta. RESULTS: Following Procedure-1 (volume overload) echocardiography confirmed severe aortic regurgitation in all animals in the HF group, with increased mean pulse pressure difference from 18 ± 3 to 38 ± 3 mmHg (P
AB - INTRODUCTION: Surgically induced, combined volume and pressure overload has been used in rabbits to create a simplified and reproducible model of acute left ventricular (LV) failure. MATERIALS AND METHODS: New Zealand white male rabbits (n = 24, mean weight 3.1 ± 0.2 kg) were randomly assigned to either the Control group (n = 10) or to the Heart Failure group (HF, n = 14). Animals in the Control group underwent "sham" procedures. Animals in the HF group underwent procedures to induce LV volume overload by inducing severe aortic valve regurgitation with aortic cusp disruption and pressure overload using an occlusive silver clip positioned around the pre-renal abdominal aorta. RESULTS: Following Procedure-1 (volume overload) echocardiography confirmed severe aortic regurgitation in all animals in the HF group, with increased mean pulse pressure difference from 18 ± 3 to 38 ± 3 mmHg (P
KW - congestive heart failure
KW - experimental research
KW - left heart failure
KW - ventricular dilatation
KW - ventricular hyprtrophy
U2 - 10.3389/fped.2013.00033
DO - 10.3389/fped.2013.00033
M3 - Article
C2 - 24400279
SN - 2296-2360
VL - 1
JO - Frontiers in pediatrics
JF - Frontiers in pediatrics
ER -