Congestive heart failure: experimental model.

Antonio Francesco Corno; Xue Cai; Caroline B Jones; Giuseppina Mondani; Mark R Boyett; Jonathan Charles Jarvis; George Hart

doi:10.3389/fped.2013.00033

Congestive heart failure: experimental model.

Antonio Francesco Corno
, Xue Cai
, Caroline B Jones
, Giuseppina Mondani
, Mark R Boyett
, Jonathan Charles Jarvis
, George Hart

Research output: Contribution to journal › Article › peer-review

Abstract

INTRODUCTION: Surgically induced, combined volume and pressure overload has been used in rabbits to create a simplified and reproducible model of acute left ventricular (LV) failure. MATERIALS AND METHODS: New Zealand white male rabbits (n = 24, mean weight 3.1 ± 0.2 kg) were randomly assigned to either the Control group (n = 10) or to the Heart Failure group (HF, n = 14). Animals in the Control group underwent "sham" procedures. Animals in the HF group underwent procedures to induce LV volume overload by inducing severe aortic valve regurgitation with aortic cusp disruption and pressure overload using an occlusive silver clip positioned around the pre-renal abdominal aorta. RESULTS: Following Procedure-1 (volume overload) echocardiography confirmed severe aortic regurgitation in all animals in the HF group, with increased mean pulse pressure difference from 18 ± 3 to 38 ± 3 mmHg (P

Original language	English
Journal	Frontiers in pediatrics
Volume	1
DOIs	https://doi.org/10.3389/fped.2013.00033
Publication status	Published - 2013

Keywords

congestive heart failure
experimental research
left heart failure
ventricular dilatation
ventricular hyprtrophy

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10.3389/fped.2013.00033

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title = "Congestive heart failure: experimental model.",

abstract = "INTRODUCTION: Surgically induced, combined volume and pressure overload has been used in rabbits to create a simplified and reproducible model of acute left ventricular (LV) failure. MATERIALS AND METHODS: New Zealand white male rabbits (n = 24, mean weight 3.1 ± 0.2 kg) were randomly assigned to either the Control group (n = 10) or to the Heart Failure group (HF, n = 14). Animals in the Control group underwent {"}sham{"} procedures. Animals in the HF group underwent procedures to induce LV volume overload by inducing severe aortic valve regurgitation with aortic cusp disruption and pressure overload using an occlusive silver clip positioned around the pre-renal abdominal aorta. RESULTS: Following Procedure-1 (volume overload) echocardiography confirmed severe aortic regurgitation in all animals in the HF group, with increased mean pulse pressure difference from 18 ± 3 to 38 ± 3 mmHg (P ",

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doi = "10.3389/fped.2013.00033",

language = "English",

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TY - JOUR

T1 - Congestive heart failure: experimental model.

AU - Corno, Antonio Francesco

AU - Cai, Xue

AU - Jones, Caroline B

AU - Mondani, Giuseppina

AU - Boyett, Mark R

AU - Jarvis, Jonathan Charles

AU - Hart, George

PY - 2013

Y1 - 2013

N2 - INTRODUCTION: Surgically induced, combined volume and pressure overload has been used in rabbits to create a simplified and reproducible model of acute left ventricular (LV) failure. MATERIALS AND METHODS: New Zealand white male rabbits (n = 24, mean weight 3.1 ± 0.2 kg) were randomly assigned to either the Control group (n = 10) or to the Heart Failure group (HF, n = 14). Animals in the Control group underwent "sham" procedures. Animals in the HF group underwent procedures to induce LV volume overload by inducing severe aortic valve regurgitation with aortic cusp disruption and pressure overload using an occlusive silver clip positioned around the pre-renal abdominal aorta. RESULTS: Following Procedure-1 (volume overload) echocardiography confirmed severe aortic regurgitation in all animals in the HF group, with increased mean pulse pressure difference from 18 ± 3 to 38 ± 3 mmHg (P

AB - INTRODUCTION: Surgically induced, combined volume and pressure overload has been used in rabbits to create a simplified and reproducible model of acute left ventricular (LV) failure. MATERIALS AND METHODS: New Zealand white male rabbits (n = 24, mean weight 3.1 ± 0.2 kg) were randomly assigned to either the Control group (n = 10) or to the Heart Failure group (HF, n = 14). Animals in the Control group underwent "sham" procedures. Animals in the HF group underwent procedures to induce LV volume overload by inducing severe aortic valve regurgitation with aortic cusp disruption and pressure overload using an occlusive silver clip positioned around the pre-renal abdominal aorta. RESULTS: Following Procedure-1 (volume overload) echocardiography confirmed severe aortic regurgitation in all animals in the HF group, with increased mean pulse pressure difference from 18 ± 3 to 38 ± 3 mmHg (P

KW - congestive heart failure

KW - experimental research

KW - left heart failure

KW - ventricular dilatation

KW - ventricular hyprtrophy

U2 - 10.3389/fped.2013.00033

DO - 10.3389/fped.2013.00033

M3 - Article

C2 - 24400279

SN - 2296-2360

VL - 1

JO - Frontiers in pediatrics

JF - Frontiers in pediatrics

ER -

Congestive heart failure: experimental model.

Abstract

Keywords

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