Consecutive three- and four-component coupling reactions with anions generated from a butane diacetal desymmetrized glycolic acid derivative

Darren J. Dixon, Steven V. Ley, Félix Rodríguez

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Up to five new stereogenic centers (see 2) can be formed in one-pot consecutive three- and four-component coupling reactions starting from a butane diacetal desymmetrized glycolic acid derivative 1. Highly functionalized α-hydroxy acid derivatives are obtained in an easy, fast, clean, and efficient way. LHMDS = lithium hexamethyldisilazide.
    Original languageEnglish
    Pages (from-to)4763-4765
    Number of pages2
    JournalAngewandte Chemie - International Edition
    Volume40
    Issue number24
    DOIs
    Publication statusPublished - 17 Dec 2001

    Keywords

    • Acetals
    • Asymmetric synthesis
    • C-C coupling
    • Michael addition
    • Synthetic methods

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