Consecutive three- and four-component coupling reactions with anions generated from a butane diacetal desymmetrized glycolic acid derivative

Darren J. Dixon; Steven V. Ley; Félix Rodríguez

doi:10.1002/1521-3773(20011217)40:24<4763::AID- ANIE4763>3.0.CO;2-D

Consecutive three- and four-component coupling reactions with anions generated from a butane diacetal desymmetrized glycolic acid derivative

Darren J. Dixon, Steven V. Ley, Félix Rodríguez

Research output: Contribution to journal › Article › peer-review

Abstract

Up to five new stereogenic centers (see 2) can be formed in one-pot consecutive three- and four-component coupling reactions starting from a butane diacetal desymmetrized glycolic acid derivative 1. Highly functionalized α-hydroxy acid derivatives are obtained in an easy, fast, clean, and efficient way. LHMDS = lithium hexamethyldisilazide.

Original language	English
Pages (from-to)	4763-4765
Number of pages	2
Journal	Angewandte Chemie - International Edition
Volume	40
Issue number	24
DOIs	https://doi.org/10.1002/1521-3773(20011217)40:24<4763::AID- ANIE4763>3.0.CO;2-D
Publication status	Published - 17 Dec 2001

Keywords

Acetals
Asymmetric synthesis
C-C coupling
Michael addition
Synthetic methods

Access to Document

10.1002/1521-3773(20011217)40:24<4763::AID- ANIE4763>3.0.CO;2-D

Cite this

@article{802dec3747be42f98190f8af71c9e2c4,

title = "Consecutive three- and four-component coupling reactions with anions generated from a butane diacetal desymmetrized glycolic acid derivative",

abstract = "Up to five new stereogenic centers (see 2) can be formed in one-pot consecutive three- and four-component coupling reactions starting from a butane diacetal desymmetrized glycolic acid derivative 1. Highly functionalized α-hydroxy acid derivatives are obtained in an easy, fast, clean, and efficient way. LHMDS = lithium hexamethyldisilazide.",

keywords = "Acetals, Asymmetric synthesis, C-C coupling, Michael addition, Synthetic methods",

author = "Dixon, {Darren J.} and Ley, {Steven V.} and F{\'e}lix Rodr{\'i}guez",

year = "2001",

month = dec,

day = "17",

doi = "10.1002/1521-3773(20011217)40:24<4763::AID- ANIE4763>3.0.CO;2-D",

language = "English",

volume = "40",

pages = "4763--4765",

journal = "Angewandte Chemie - International Edition",

issn = "1433-7851",

publisher = "John Wiley & Sons Ltd",

number = "24",

}

TY - JOUR

T1 - Consecutive three- and four-component coupling reactions with anions generated from a butane diacetal desymmetrized glycolic acid derivative

AU - Dixon, Darren J.

AU - Ley, Steven V.

AU - Rodríguez, Félix

PY - 2001/12/17

Y1 - 2001/12/17

N2 - Up to five new stereogenic centers (see 2) can be formed in one-pot consecutive three- and four-component coupling reactions starting from a butane diacetal desymmetrized glycolic acid derivative 1. Highly functionalized α-hydroxy acid derivatives are obtained in an easy, fast, clean, and efficient way. LHMDS = lithium hexamethyldisilazide.

AB - Up to five new stereogenic centers (see 2) can be formed in one-pot consecutive three- and four-component coupling reactions starting from a butane diacetal desymmetrized glycolic acid derivative 1. Highly functionalized α-hydroxy acid derivatives are obtained in an easy, fast, clean, and efficient way. LHMDS = lithium hexamethyldisilazide.

KW - Acetals

KW - Asymmetric synthesis

KW - C-C coupling

KW - Michael addition

KW - Synthetic methods

U2 - 10.1002/1521-3773(20011217)40:24<4763::AID- ANIE4763>3.0.CO;2-D

DO - 10.1002/1521-3773(20011217)40:24<4763::AID- ANIE4763>3.0.CO;2-D

M3 - Article

SN - 1433-7851

VL - 40

SP - 4763

EP - 4765

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 24

ER -

Consecutive three- and four-component coupling reactions with anions generated from a butane diacetal desymmetrized glycolic acid derivative

Abstract

Keywords

Access to Document

Fingerprint

Cite this