Construction of a computational anatomical model of the peripheral cardiac conduction system

Rafael Sebastian, Viviana Zimmerman, Daniel Romero, Alejandro F. Frangi

Research output: Contribution to journalArticlepeer-review


A methodology is presented here for automatic construction of a ventricular model of the cardiac conduction system (CCS), which is currently a missing block in many multiscale cardiac electromechanic models. It includes the His bundle, left bundle branches, and the peripheral CCS. The algorithm is fundamentally an enhancement of a rule-based method known as the Lindenmayer systems (L-systems). The generative procedure has been divided into three consecutive independent stages, which subsequently build the CCS from proximal to distal sections. Each stage is governed by a set of user parameters together with anatomical and physiological constrains to direct the generation process and adhere to the structural observations derived from histology studies. Several parameters are defined using statistical distributions to introduce stochastic variability in the models. The CCS built with this approach can generate electrical activation sequences with physiological characteristics.

Original languageEnglish
Article number6008630
Pages (from-to)3479-3482
Number of pages4
JournalIEEE Transactions on Biomedical Engineering
Issue number12 PART 2
Publication statusPublished - Dec 2011


  • Biophysical modeling
  • cardiac conduction system (CCS)
  • cardiac electrophysiology


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