TY - JOUR
T1 - Construction of a computational anatomical model of the peripheral cardiac conduction system
AU - Sebastian, Rafael
AU - Zimmerman, Viviana
AU - Romero, Daniel
AU - Frangi, Alejandro F.
N1 - Funding Information:
Manuscript received April 10, 2011; revised July 21, 2011; accepted August 18, 2011. Date of publication September 1, 2011; date of current version November 18, 2011. This work was supported in part by the European Commission under the euHeart Integrated Project FP7-ICT-2007-224485 and by the Spanish Ministry of Science and Innovation under the cvREMOD CENIT Projects CEN20091044. Asterisk indicates corresponding author.
PY - 2011/12
Y1 - 2011/12
N2 - A methodology is presented here for automatic construction of a ventricular model of the cardiac conduction system (CCS), which is currently a missing block in many multiscale cardiac electromechanic models. It includes the His bundle, left bundle branches, and the peripheral CCS. The algorithm is fundamentally an enhancement of a rule-based method known as the Lindenmayer systems (L-systems). The generative procedure has been divided into three consecutive independent stages, which subsequently build the CCS from proximal to distal sections. Each stage is governed by a set of user parameters together with anatomical and physiological constrains to direct the generation process and adhere to the structural observations derived from histology studies. Several parameters are defined using statistical distributions to introduce stochastic variability in the models. The CCS built with this approach can generate electrical activation sequences with physiological characteristics.
AB - A methodology is presented here for automatic construction of a ventricular model of the cardiac conduction system (CCS), which is currently a missing block in many multiscale cardiac electromechanic models. It includes the His bundle, left bundle branches, and the peripheral CCS. The algorithm is fundamentally an enhancement of a rule-based method known as the Lindenmayer systems (L-systems). The generative procedure has been divided into three consecutive independent stages, which subsequently build the CCS from proximal to distal sections. Each stage is governed by a set of user parameters together with anatomical and physiological constrains to direct the generation process and adhere to the structural observations derived from histology studies. Several parameters are defined using statistical distributions to introduce stochastic variability in the models. The CCS built with this approach can generate electrical activation sequences with physiological characteristics.
KW - Biophysical modeling
KW - cardiac conduction system (CCS)
KW - cardiac electrophysiology
UR - http://www.scopus.com/inward/record.url?scp=82155176312&partnerID=8YFLogxK
U2 - 10.1109/TBME.2011.2166553
DO - 10.1109/TBME.2011.2166553
M3 - Article
C2 - 21896384
SN - 0018-9294
VL - 58
SP - 3479
EP - 3482
JO - IEEE Transactions on Biomedical Engineering
JF - IEEE Transactions on Biomedical Engineering
IS - 12 PART 2
M1 - 6008630
ER -