Contact hypersensitivity induces plasma interleukin 6

I. Kimber, M. Cumberbatch, M. Humphreys, S. J. Hopkins

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Previous studies in this laboratory have revealed that elicitation reactions in contact-sensitized mice correlate closely with elevations in the serum concentration of acute-phase proteins. Regulation of the hepatic synthesis of acute-phase proteins is one of the many biological functions ascribed to interleukin 6 (IL-6). We now provide evidence that contact reactions are also associated with a rapid and substantial increase in the plasma concentration of IL-6. Quantitative assessment of plasma IL-6 may provide a useful serological method for the evaluation of experimental allergic contact dermatitis in mice, and possibly in other species.
    Original languageEnglish
    Pages (from-to)97-99
    Number of pages2
    JournalInternational Archives of Allergy and Applied Immunology
    Volume92
    Issue number1
    Publication statusPublished - 1990

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