Content validity of global measures for at-work productivity in patients with rheumatic diseases: an international qualitative study.

Sarah Leggett, Antje van der Zee-Neuen, Annelies Boonen, Dorcas Beaton, Mihai Bojinca, Ailsa Bosworth, Sabrina Dadoun, Bruno Fautrel, Sofia Hagel, Catherine Hofstetter, Diane Lacaille, Denise Linton, Carina Mihai, Ingemar F Petersson, Pam Rogers, Carlo Sciré, Suzanne M M Verstappen

    Research output: Contribution to journalArticlepeer-review


    OBJECTIVES: To identify from a patient's perspective, difficulties and differences in the comprehension of five global presenteeism measures in patients with inflammatory arthritis and OA across seven countries. METHODS: Seventy patients with a diagnosis of inflammatory arthritis or OA in paid employment were recruited from seven countries across Europe and Canada. Patients were randomly allocated to be cognitively debriefed on 3/5 global measures [Work Productivity Scale - Rheumatoid Arthritis, Work Productivity and Activity Impairment Questionnaire (WPAI), Work Ability Index, Quality and Quantity questionnaire, and WHO Health and Work Performance Questionnaire (HPQ)], with the WPAI debriefed in all patients as a standard measure of comparison between countries and patients. NVivo was used to code the data into four themes: construct and anchor, time recall, reference frame, and attribution. RESULTS: Discrepancies were found in the interpretation of the word performance (HPQ) between countries, with Romania and Sweden relating performance to sports rather than work. Seventy percent of patients considered that a 7-day recall (WPAI) can accurately represent how their disease affects work productivity. The compared to normal reference (Quality and Quantity questionnaire) was reportedly too ambiguous, and the comparison with colleagues (HPQ), made many feel uncomfortable. Overall, 29% of patients said the WPAI was the most relevant to them, making it the most favoured measure. CONCLUSION: Overall, patients across countries agree that the construct of work productivity in the last 7 days can accurately reflect the impact of disease while at work. Some current constructs to assess at-work productivity are not interchangeable between languages.
    Original languageEnglish
    Pages (from-to)1364-1373
    JournalRheumatology (Oxford, England)
    Issue number8
    Early online date21 Jan 2016
    Publication statusPublished - 2016


    • cognitive debriefing interview
    • content validity
    • global measures
    • patient-reported outcomes
    • presenteeism
    • work productivity


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