Continuous-flow synthesis of trimethylsilylphenyl perfluorosulfonate benzyne precursors

Boris Michel, Michael F. Greaney

    Research output: Contribution to journalArticlepeer-review


    2-(Trimethylsilyl)phenyl perfluorosulfonated aryne precursors may now be accessed using flow chemistry, enabling the fast preparation of pure compounds with no requirement for low temperature lithiation or column chromatography. The process has been adapted to novel nonaflate precursors, utilizing the cheaper and more user-friendly nonaflyl fluoride reagent. The resultant nonaflates are shown to successfully participate in a range of aryne reaction classes. © 2014 American Chemical Society.
    Original languageEnglish
    Pages (from-to)2684-2687
    Number of pages3
    JournalOrganic Letters
    Issue number10
    Publication statusPublished - 16 May 2014


    Dive into the research topics of 'Continuous-flow synthesis of trimethylsilylphenyl perfluorosulfonate benzyne precursors'. Together they form a unique fingerprint.

    Cite this