Contra-Friedel-Crafts tert-butylation of substituted aromatic rings via directed metallation and sulfinylation

Jonathan Clayden, Christopher C. Stimson, Martine Keenan

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Directed metallation and sulfinylation yields sulfoxides which undergo ipso nucleophilic aromatic substitution with tertiary and secondary alkyllithiums, giving aromatic rings bearing alkyl groups generally incompatible with directed metallation methods and with regioselectivity complementary with classical Friedel-Crafts substitution. © The Royal Society of Chemistry 2006.
    Original languageEnglish
    Pages (from-to)1393-1394
    Number of pages1
    JournalChemical Communications
    Issue number13
    DOIs
    Publication statusPublished - 2006

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