Contraction-Induced Oxidants as Mediators of Adaptation and Damage in Skeletal Muscle

David M. Pattwell; Malcolm J. Jackson

doi:10.1097/00003677-200401000-00004

Contraction-Induced Oxidants as Mediators of Adaptation and Damage in Skeletal Muscle

David M. Pattwell, Malcolm J. Jackson

Research output: Contribution to journal › Article › peer-review

Abstract

Contracting skeletal muscle generates reactive oxygen and nitrogen species (ROS) that can induce changes in gene expression or cell damage depending upon the pattern of production and the endogenous protective systems. The hypothesis is presented that skeletal muscle uses contraction-induced ROS as signals to induce adaptive responses including maintenance of oxidant homeostasis and prevention of oxidative damage.

Original language	English
Pages (from-to)	14-18
Number of pages	4
Journal	Exercise and Sport Sciences Reviews
Volume	32
Issue number	1
DOIs	https://doi.org/10.1097/00003677-200401000-00004
Publication status	Published - Jan 2004

Keywords

Antioxidants
Free radicals
Gene expression
Oxidant homeostasis
Training

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10.1097/00003677-200401000-00004

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title = "Contraction-Induced Oxidants as Mediators of Adaptation and Damage in Skeletal Muscle",

abstract = "Contracting skeletal muscle generates reactive oxygen and nitrogen species (ROS) that can induce changes in gene expression or cell damage depending upon the pattern of production and the endogenous protective systems. The hypothesis is presented that skeletal muscle uses contraction-induced ROS as signals to induce adaptive responses including maintenance of oxidant homeostasis and prevention of oxidative damage.",

keywords = "Antioxidants, Free radicals, Gene expression, Oxidant homeostasis, Training",

author = "Pattwell, {David M.} and Jackson, {Malcolm J.}",

year = "2004",

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AU - Pattwell, David M.

AU - Jackson, Malcolm J.

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N2 - Contracting skeletal muscle generates reactive oxygen and nitrogen species (ROS) that can induce changes in gene expression or cell damage depending upon the pattern of production and the endogenous protective systems. The hypothesis is presented that skeletal muscle uses contraction-induced ROS as signals to induce adaptive responses including maintenance of oxidant homeostasis and prevention of oxidative damage.

AB - Contracting skeletal muscle generates reactive oxygen and nitrogen species (ROS) that can induce changes in gene expression or cell damage depending upon the pattern of production and the endogenous protective systems. The hypothesis is presented that skeletal muscle uses contraction-induced ROS as signals to induce adaptive responses including maintenance of oxidant homeostasis and prevention of oxidative damage.

KW - Antioxidants

KW - Free radicals

KW - Gene expression

KW - Oxidant homeostasis

KW - Training

U2 - 10.1097/00003677-200401000-00004

DO - 10.1097/00003677-200401000-00004

M3 - Article

C2 - 14748544

VL - 32

SP - 14

EP - 18

JO - Exercise and Sport Sciences Reviews

JF - Exercise and Sport Sciences Reviews

IS - 1

ER -

Contraction-Induced Oxidants as Mediators of Adaptation and Damage in Skeletal Muscle

Abstract

Keywords

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