Control of adhesion and protrusion in cell migration by Rho GTPases

Harry Warner; Beverley J. Wilson; Patrick T. Caswell

doi:10.1016/j.ceb.2018.09.003

Control of adhesion and protrusion in cell migration by Rho GTPases

Harry Warner, Beverley J. Wilson, Patrick T. Caswell

Research output: Contribution to journal › Article › peer-review

Abstract

Cell migration is a critical process that underpins a number of physiological and pathological contexts such as the correct functioning of the immune system and the spread of metastatic cancer cells. Central to this process are the Rho family of GTPases, which act as core regulators of cell migration. Rho GTPases are molecular switches that associate with lipid membranes and act to choreograph molecular events that underpin cell migration. Specifically, these GTPases play critical roles in coordinating force generation through driving the formation of cellular protrusions as well as cell–cell and cell–matrix adhesions. Here we provide an update on the many roles of Rho-family GTPases in coordinating protrusion and adhesion formation in the context of cell migration, as well as describing how their activity is controlled to by a variety of complex signalling networks.

Original language	English
Pages (from-to)	64-70
Number of pages	7
Journal	Current opinion in cell biology
Volume	56
Early online date	3 Oct 2018
DOIs	https://doi.org/10.1016/j.ceb.2018.09.003
Publication status	Published - 1 Feb 2019

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.ceb.2018.09.003Licence: CC BY

Cite this

@article{db656fabcf0f4ef28f3b0416245c4753,

title = "Control of adhesion and protrusion in cell migration by Rho GTPases",

abstract = "Cell migration is a critical process that underpins a number of physiological and pathological contexts such as the correct functioning of the immune system and the spread of metastatic cancer cells. Central to this process are the Rho family of GTPases, which act as core regulators of cell migration. Rho GTPases are molecular switches that associate with lipid membranes and act to choreograph molecular events that underpin cell migration. Specifically, these GTPases play critical roles in coordinating force generation through driving the formation of cellular protrusions as well as cell–cell and cell–matrix adhesions. Here we provide an update on the many roles of Rho-family GTPases in coordinating protrusion and adhesion formation in the context of cell migration, as well as describing how their activity is controlled to by a variety of complex signalling networks.",

author = "Harry Warner and Wilson, {Beverley J.} and Caswell, {Patrick T.}",

year = "2019",

month = feb,

day = "1",

doi = "10.1016/j.ceb.2018.09.003",

language = "English",

volume = "56",

pages = "64--70",

journal = "Current opinion in cell biology",

issn = "0955-0674",

publisher = "Elsevier BV",

}

TY - JOUR

T1 - Control of adhesion and protrusion in cell migration by Rho GTPases

AU - Warner, Harry

AU - Wilson, Beverley J.

AU - Caswell, Patrick T.

PY - 2019/2/1

Y1 - 2019/2/1

N2 - Cell migration is a critical process that underpins a number of physiological and pathological contexts such as the correct functioning of the immune system and the spread of metastatic cancer cells. Central to this process are the Rho family of GTPases, which act as core regulators of cell migration. Rho GTPases are molecular switches that associate with lipid membranes and act to choreograph molecular events that underpin cell migration. Specifically, these GTPases play critical roles in coordinating force generation through driving the formation of cellular protrusions as well as cell–cell and cell–matrix adhesions. Here we provide an update on the many roles of Rho-family GTPases in coordinating protrusion and adhesion formation in the context of cell migration, as well as describing how their activity is controlled to by a variety of complex signalling networks.

AB - Cell migration is a critical process that underpins a number of physiological and pathological contexts such as the correct functioning of the immune system and the spread of metastatic cancer cells. Central to this process are the Rho family of GTPases, which act as core regulators of cell migration. Rho GTPases are molecular switches that associate with lipid membranes and act to choreograph molecular events that underpin cell migration. Specifically, these GTPases play critical roles in coordinating force generation through driving the formation of cellular protrusions as well as cell–cell and cell–matrix adhesions. Here we provide an update on the many roles of Rho-family GTPases in coordinating protrusion and adhesion formation in the context of cell migration, as well as describing how their activity is controlled to by a variety of complex signalling networks.

UR - http://www.scopus.com/inward/record.url?scp=85054181848&partnerID=8YFLogxK

U2 - 10.1016/j.ceb.2018.09.003

DO - 10.1016/j.ceb.2018.09.003

M3 - Article

AN - SCOPUS:85054181848

VL - 56

SP - 64

EP - 70

JO - Current opinion in cell biology

JF - Current opinion in cell biology

SN - 0955-0674

ER -

Control of adhesion and protrusion in cell migration by Rho GTPases

Abstract

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this