Controlled Chemical Derivatisation of Carbon Nanotubes with Imaging, Targeting, and Therapeutic Capabilities.

Cécilia Ménard-Moyon, Hanene Ali-Boucetta, Chiara Fabbro, Olivier Chaloin, Kostas Kostarelos, Alberto Bianco

    Research output: Contribution to journalArticlepeer-review

    Abstract

    In drug delivery, carbon nanotubes (CNTs) hold a great potential as carriers because of their ability to easily cross biological barriers and be internalised into cells. Their high aspect ratio allows multi-functionalisation and their development as a multimodal platform for targeted therapy. In this article, we report the controlled covalent derivatisation of triple-functionalised CNTs with the anticancer drug gemcitabine, folic acid as a targeting ligand and fluorescein as a probe. The anticancer activity of gemcitabine was maintained after covalent grafting onto the CNTs. The functionalised nanotubes were internalised into both folate-positive and negative cells, suggesting the passive diffusion of CNTs. Overall, our approach is versatile and offers a precise chemical control of the sidewall functionalisation of CNTs and the possibility to manoeuvre the types of functionalities required on the nanotubes for a multimodal therapeutic strategy.
    Original languageEnglish
    JournalChemistry: A European Journal
    Volume21
    Issue number42
    DOIs
    Publication statusPublished - 12 Oct 2015

    Keywords

    • cancer
    • carbon nanotubes
    • drug delivery
    • fluorescent probes
    • functionalization

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