Controlled release and characterisation of photocaged molecules using in situ LED illumination in solution NMR spectroscopy

Jack E. Bramham; Matja Zalar; Alexander P. Golovanov

doi:10.1039/D2CC04731D

Controlled release and characterisation of photocaged molecules using in situ LED illumination in solution NMR spectroscopy

Jack E. Bramham, Matja Zalar, Alexander P. Golovanov

Research output: Contribution to journal › Article › peer-review

Abstract

Photocaging is an attractive strategy to control molecular behaviour, for example, in chemical synthesis, interaction studies or photodynamic therapies. Here, we demonstrate that in situ illumination by the LED NMRtorch approach enables effective and controlled photocage release with simultaneous monitoring of subsequent reactions by solution NMR spectroscopy.

Original language	English
Pages (from-to)	11973-11976
Number of pages	4
Journal	Chemical Communications
Volume	58
Issue number	85
DOIs	https://doi.org/10.1039/D2CC04731D
Publication status	Published - 3 Oct 2022

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10.1039/D2CC04731DLicence: CC BY

Biomolecular NMR Facility
Cliff, M. (Platform Lead)
Manchester Institute of Biotechnology
Facility/equipment: Facility

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title = "Controlled release and characterisation of photocaged molecules using in situ LED illumination in solution NMR spectroscopy",

abstract = "Photocaging is an attractive strategy to control molecular behaviour, for example, in chemical synthesis, interaction studies or photodynamic therapies. Here, we demonstrate that in situ illumination by the LED NMRtorch approach enables effective and controlled photocage release with simultaneous monitoring of subsequent reactions by solution NMR spectroscopy.",

author = "Bramham, {Jack E.} and Matja Zalar and Golovanov, {Alexander P.}",

year = "2022",

month = oct,

day = "3",

doi = "10.1039/D2CC04731D",

language = "English",

volume = "58",

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journal = "Chemical Communications",

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publisher = "Royal Society of Chemistry",

number = "85",

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TY - JOUR

T1 - Controlled release and characterisation of photocaged molecules using in situ LED illumination in solution NMR spectroscopy

AU - Bramham, Jack E.

AU - Zalar, Matja

AU - Golovanov, Alexander P.

PY - 2022/10/3

Y1 - 2022/10/3

N2 - Photocaging is an attractive strategy to control molecular behaviour, for example, in chemical synthesis, interaction studies or photodynamic therapies. Here, we demonstrate that in situ illumination by the LED NMRtorch approach enables effective and controlled photocage release with simultaneous monitoring of subsequent reactions by solution NMR spectroscopy.

AB - Photocaging is an attractive strategy to control molecular behaviour, for example, in chemical synthesis, interaction studies or photodynamic therapies. Here, we demonstrate that in situ illumination by the LED NMRtorch approach enables effective and controlled photocage release with simultaneous monitoring of subsequent reactions by solution NMR spectroscopy.

U2 - 10.1039/D2CC04731D

DO - 10.1039/D2CC04731D

M3 - Article

SN - 1359-7345

VL - 58

SP - 11973

EP - 11976

JO - Chemical Communications

JF - Chemical Communications

IS - 85

ER -

Controlled release and characterisation of photocaged molecules using in situ LED illumination in solution NMR spectroscopy

Abstract

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Biomolecular NMR Facility

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