Conversion of alcohols to enantiopure amines through dual-enzyme hydrogen-borrowing cascades.

Original language	English
Pages (from-to)	1525-1529
Number of pages	4
Journal	Science
Volume	349
Issue number	6255
DOIs	https://doi.org/10.1126/science.aac9283
Publication status	Published - 25 Sept 2015

Access to Document

• 10.1126/science.aac9283

Projects

• 1 Finished

Projects per year

• Manchester Synthetic Biology Research Centre for Fine and Speciality Chemicals

  Scrutton, N. (PI), Azapagic, A. (CoI), Balmer, A. (CoI), Barran, P. (CoI), Breitling, R. (CoI), Delneri, D. (CoI), Dixon, N. (CoI), Faulon, J.-L. (CoI), Flitsch, S. (CoI), Goble, C. (CoI), Goodacre, R. (CoI), Hay, S. (CoI), Kell, D. (CoI), Leys, D. (CoI), Lloyd, J. (CoI), Lockyer, N. (CoI), Martin, P. (CoI), Micklefield, J. (CoI), Munro, A. (CoI), Pedrosa Mendes, P. (CoI), Randles, S. (CoI), Salehi Yazdi, F. (CoI), Shapira, P. (CoI), Takano, E. (CoI), Turner, N. (CoI) & Winterburn, J. (CoI)

  14/11/14 → 13/05/20

  Project: Research

  • Metabolic 100%
  • Oxidoreductase 93%
  • Metabolite 92%
  • Escherichia coli 90%
  • Ion Mobility Mass Spectrometry 86%

Impacts

• Driving the industrial biotechnology revolution: cheaper and more sustainable chemical manufacturing through enzyme discovery, engineering and scale-up

  Turner, N. (Participant), Flitsch, S. (Participant), Scrutton, N. (Participant), Micklefield, J. (Participant), Greaney, M. (Participant), Weise, N. (Participant), Hardacre, C. (Participant), Lovelock, S. (Participant) & Green, A. (Participant)

  Impact: Economic, Technological, Policy, Awareness and understanding

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Mutti, FG., Knaus, T., Scrutton, NS., Breuer, M., & Turner, N. (2015). Conversion of alcohols to enantiopure amines through dual-enzyme hydrogen-borrowing cascades. Science, 349(6255), 1525-1529. https://doi.org/10.1126/science.aac9283

Mutti, FG ; Knaus, T ; Scrutton, NS et al. / Conversion of alcohols to enantiopure amines through dual-enzyme hydrogen-borrowing cascades. In: Science. 2015 ; Vol. 349, No. 6255. pp. 1525-1529.

@article{6ecbb7fb12e0401e87fe06994467b6b6,

title = "Conversion of alcohols to enantiopure amines through dual-enzyme hydrogen-borrowing cascades.",

author = "FG Mutti and T Knaus and NS Scrutton and M Breuer and Nicholas Turner",

year = "2015",

month = sep,

day = "25",

doi = "10.1126/science.aac9283",

language = "English",

volume = "349",

pages = "1525--1529",

journal = "Science",

publisher = "American Association for the Advancement of Science (A A A S)",

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Mutti, FG, Knaus, T, Scrutton, NS, Breuer, M & Turner, N 2015, 'Conversion of alcohols to enantiopure amines through dual-enzyme hydrogen-borrowing cascades.', Science, vol. 349, no. 6255, pp. 1525-1529. https://doi.org/10.1126/science.aac9283

Conversion of alcohols to enantiopure amines through dual-enzyme hydrogen-borrowing cascades. / Mutti, FG; Knaus, T; Scrutton, NS et al.
In: Science, Vol. 349, No. 6255, 25.09.2015, p. 1525-1529.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Conversion of alcohols to enantiopure amines through dual-enzyme hydrogen-borrowing cascades.

AU - Mutti, FG

AU - Knaus, T

AU - Scrutton, NS

AU - Breuer, M

AU - Turner, Nicholas

PY - 2015/9/25

Y1 - 2015/9/25

U2 - 10.1126/science.aac9283

DO - 10.1126/science.aac9283

M3 - Article

VL - 349

SP - 1525

EP - 1529

JO - Science

JF - Science

IS - 6255

ER -

Mutti FG, Knaus T, Scrutton NS, Breuer M, Turner N. Conversion of alcohols to enantiopure amines through dual-enzyme hydrogen-borrowing cascades. Science. 2015 Sept 25;349(6255):1525-1529. doi: 10.1126/science.aac9283