Copper-catalyzed borylative multi-component synthesis of quaternary α-amino esters

Kay Yeung; Fabien Talbot; Gareth P Howell; Alexander P. Pulis; David J. Procter

doi:10.1021/acscatal.8b04563

Copper-catalyzed borylative multi-component synthesis of quaternary α-amino esters

Kay Yeung, Fabien Talbot, Gareth P Howell, Alexander P. Pulis, David J. Procter

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Abstract

Copper-catalyzed coupling of readily available ketiminoesters, allenes and a diboron affords densely functionalized
quaternary α-amino esters bearing adjacent stereocenters and versatile vinyl boronate motifs. The method utilizes a commercially
available copper(I) catalyst, operates at ambient temperature and features a catalytic allyl cupration of ketiminoesters.

Original language	English
Journal	ACS Catalysis
Early online date	9 Jan 2019
DOIs	https://doi.org/10.1021/acscatal.8b04563
Publication status	Published - 2019

Keywords

copper catalysis
multicomponent reaction
allenes
borylation
allylation

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10.1021/acscatal.8b04563

DJP-CY-FT-REV-Manuscript-Jan7Accepted author manuscript, 1.05 MB

http://pubs.acs.org/doi/10.1021/acscatal.8b04563

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title = "Copper-catalyzed borylative multi-component synthesis of quaternary α-amino esters",

abstract = "Copper-catalyzed coupling of readily available ketiminoesters, allenes and a diboron affords densely functionalized quaternary α-amino esters bearing adjacent stereocenters and versatile vinyl boronate motifs. The method utilizes a commercially available copper(I) catalyst, operates at ambient temperature and features a catalytic allyl cupration of ketiminoesters.",

keywords = "copper catalysis, multicomponent reaction, allenes, borylation, allylation",

author = "Kay Yeung and Fabien Talbot and Howell, \{Gareth P\} and Pulis, \{Alexander P.\} and Procter, \{David J.\}",

year = "2019",

doi = "10.1021/acscatal.8b04563",

language = "English",

journal = "ACS Catalysis",

issn = "2155-5435",

publisher = "American Chemical Society",

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T1 - Copper-catalyzed borylative multi-component synthesis of quaternary α-amino esters

AU - Yeung, Kay

AU - Talbot, Fabien

AU - Howell, Gareth P

AU - Pulis, Alexander P.

AU - Procter, David J.

PY - 2019

Y1 - 2019

N2 - Copper-catalyzed coupling of readily available ketiminoesters, allenes and a diboron affords densely functionalized quaternary α-amino esters bearing adjacent stereocenters and versatile vinyl boronate motifs. The method utilizes a commercially available copper(I) catalyst, operates at ambient temperature and features a catalytic allyl cupration of ketiminoesters.

AB - Copper-catalyzed coupling of readily available ketiminoesters, allenes and a diboron affords densely functionalized quaternary α-amino esters bearing adjacent stereocenters and versatile vinyl boronate motifs. The method utilizes a commercially available copper(I) catalyst, operates at ambient temperature and features a catalytic allyl cupration of ketiminoesters.

KW - copper catalysis

KW - multicomponent reaction

KW - allenes

KW - borylation

KW - allylation

UR - https://www.scopus.com/pages/publications/85061225068

U2 - 10.1021/acscatal.8b04563

DO - 10.1021/acscatal.8b04563

M3 - Article

SN - 2155-5435

JO - ACS Catalysis

JF - ACS Catalysis

ER -

Copper-catalyzed borylative multi-component synthesis of quaternary α-amino esters

Abstract

Keywords

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