Corneal confocal microscopy detects improvement in corneal nerve morphology with an improvement in risk factors for diabetic neuropathy

M. Tavakoli; P. Kallinikos; A. Iqbal; A. Herbert; H. Fadavi; N. Efron; A. J M Boulton; R. A. Malik

doi:10.1111/j.1464-5491.2011.03372.x

Corneal confocal microscopy detects improvement in corneal nerve morphology with an improvement in risk factors for diabetic neuropathy

M. Tavakoli, P. Kallinikos, A. Iqbal, A. Herbert, H. Fadavi, N. Efron, A. J M Boulton, R. A. Malik

Research output: Contribution to journal › Article › peer-review

Abstract

Aim We have assessed whether corneal confocal microscopy can be used to detect alterations in nerve morphology following an improvement in risk factors associated with diabetic neuropathy. Methods Twenty-five patients with diabetes with mild to moderate neuropathy and 18 control subjects underwent corneal confocal microscopy to quantify corneal nerve fibre (density, branch density, length and tortuosity) at baseline and after 24months from first visit. This was not planned as an intervention trial and was simply an observational follow-up. Results At baseline, nerve fibre density (18.8±2.1 vs. 46.0±3.8number/mm 2, P=0.001), nerve branch density (6.9±1.5 vs. 35.6±6.7number/mm 2, P

Original language	English
Pages (from-to)	1261-1267
Number of pages	6
Journal	Diabetic Medicine
Volume	28
Issue number	10
DOIs	https://doi.org/10.1111/j.1464-5491.2011.03372.x
Publication status	Published - Oct 2011

Keywords

Corneal confocal microscopy
Corneal nerves
Diabetic neuropathy
Risk factors

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/j.1464-5491.2011.03372.x

Cite this

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title = "Corneal confocal microscopy detects improvement in corneal nerve morphology with an improvement in risk factors for diabetic neuropathy",

abstract = "Aim We have assessed whether corneal confocal microscopy can be used to detect alterations in nerve morphology following an improvement in risk factors associated with diabetic neuropathy. Methods Twenty-five patients with diabetes with mild to moderate neuropathy and 18 control subjects underwent corneal confocal microscopy to quantify corneal nerve fibre (density, branch density, length and tortuosity) at baseline and after 24months from first visit. This was not planned as an intervention trial and was simply an observational follow-up. Results At baseline, nerve fibre density (18.8±2.1 vs. 46.0±3.8number/mm 2, P=0.001), nerve branch density (6.9±1.5 vs. 35.6±6.7number/mm 2, P",

keywords = "Corneal confocal microscopy, Corneal nerves, Diabetic neuropathy, Risk factors",

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AU - Tavakoli, M.

AU - Kallinikos, P.

AU - Iqbal, A.

AU - Herbert, A.

AU - Fadavi, H.

AU - Efron, N.

AU - Boulton, A. J M

AU - Malik, R. A.

PY - 2011/10

Y1 - 2011/10

N2 - Aim We have assessed whether corneal confocal microscopy can be used to detect alterations in nerve morphology following an improvement in risk factors associated with diabetic neuropathy. Methods Twenty-five patients with diabetes with mild to moderate neuropathy and 18 control subjects underwent corneal confocal microscopy to quantify corneal nerve fibre (density, branch density, length and tortuosity) at baseline and after 24months from first visit. This was not planned as an intervention trial and was simply an observational follow-up. Results At baseline, nerve fibre density (18.8±2.1 vs. 46.0±3.8number/mm 2, P=0.001), nerve branch density (6.9±1.5 vs. 35.6±6.7number/mm 2, P

AB - Aim We have assessed whether corneal confocal microscopy can be used to detect alterations in nerve morphology following an improvement in risk factors associated with diabetic neuropathy. Methods Twenty-five patients with diabetes with mild to moderate neuropathy and 18 control subjects underwent corneal confocal microscopy to quantify corneal nerve fibre (density, branch density, length and tortuosity) at baseline and after 24months from first visit. This was not planned as an intervention trial and was simply an observational follow-up. Results At baseline, nerve fibre density (18.8±2.1 vs. 46.0±3.8number/mm 2, P=0.001), nerve branch density (6.9±1.5 vs. 35.6±6.7number/mm 2, P

KW - Corneal confocal microscopy

KW - Corneal nerves

KW - Diabetic neuropathy

KW - Risk factors

U2 - 10.1111/j.1464-5491.2011.03372.x

DO - 10.1111/j.1464-5491.2011.03372.x

M3 - Article

SN - 0742-3071

VL - 28

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JO - Diabetic Medicine

JF - Diabetic Medicine

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Corneal confocal microscopy detects improvement in corneal nerve morphology with an improvement in risk factors for diabetic neuropathy

Abstract

Keywords

UN SDGs

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