Corneal confocal microscopy detects neuropathy in patients with type 1 diabetes without retinopathy or microalbuminuria.

Ioannis N Petropoulos; Patrick Green; Agnes W S Chan; Uazman Alam; Hassan Fadavi; Andrew Marshall; Omar Asghar; Nathan Efron; Mitra Tavakoli; Rayaz Malik

doi:10.1371/journal.pone.0123517

Corneal confocal microscopy detects neuropathy in patients with type 1 diabetes without retinopathy or microalbuminuria.

Ioannis N Petropoulos, Patrick Green, Agnes W S Chan, Uazman Alam, Hassan Fadavi, Andrew Marshall, Omar Asghar, Nathan Efron, Mitra Tavakoli, Rayaz Malik

Division of Diabetes, Endocrinology & Gastroenterology (L5)

Research output: Contribution to journal › Article › peer-review

Abstract

OBJECTIVE: Corneal innervation is increasingly used as a surrogate marker of human diabetic peripheral neuropathy (DPN) however its temporal relationship with the other microvascular complications of diabetes is not fully established. In this cross-sectional, observational study we aimed to assess whether neuropathy occurred in patients with type 1 diabetes, without retinopathy or microalbuminuria. MATERIALS AND METHODS: All participants underwent detailed assessment of peripheral neuropathy [neuropathy disability score (NDS), vibration perception threshold (VPT), peroneal motor nerve conduction velocity (PMNCV), sural sensory nerve conduction velocity (SSNCV) and in vivo corneal confocal microscopy (IVCCM)], retinopathy (digital fundus photography) and albuminuria status [albumin: creatinine ratio (ACR)]. RESULTS: 53 patients with Type 1 diabetes with (n=37) and without retinopathy (n=16) were compared to control subjects (n=27). SSNCV, corneal nerve fibre (CNFD) and branch (CNBD) density and length (CNFL) were reduced significantly (p

Original language	English
Journal	PLoS ONE
Volume	10
Issue number	4
DOIs	https://doi.org/10.1371/journal.pone.0123517
Publication status	Published - 2015

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10.1371/journal.pone.0123517

ENA: Early Neuropathy Assessment (ENA)
Malik, R. (PI), Ferdousi, M. (Researcher) & Kalteniece, A. (Researcher)
Project: Research

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title = "Corneal confocal microscopy detects neuropathy in patients with type 1 diabetes without retinopathy or microalbuminuria.",

abstract = "OBJECTIVE: Corneal innervation is increasingly used as a surrogate marker of human diabetic peripheral neuropathy (DPN) however its temporal relationship with the other microvascular complications of diabetes is not fully established. In this cross-sectional, observational study we aimed to assess whether neuropathy occurred in patients with type 1 diabetes, without retinopathy or microalbuminuria. MATERIALS AND METHODS: All participants underwent detailed assessment of peripheral neuropathy [neuropathy disability score (NDS), vibration perception threshold (VPT), peroneal motor nerve conduction velocity (PMNCV), sural sensory nerve conduction velocity (SSNCV) and in vivo corneal confocal microscopy (IVCCM)], retinopathy (digital fundus photography) and albuminuria status [albumin: creatinine ratio (ACR)]. RESULTS: 53 patients with Type 1 diabetes with (n=37) and without retinopathy (n=16) were compared to control subjects (n=27). SSNCV, corneal nerve fibre (CNFD) and branch (CNBD) density and length (CNFL) were reduced significantly (p",

author = "Petropoulos, {Ioannis N} and Patrick Green and Chan, {Agnes W S} and Uazman Alam and Hassan Fadavi and Andrew Marshall and Omar Asghar and Nathan Efron and Mitra Tavakoli and Rayaz Malik",

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TY - JOUR

T1 - Corneal confocal microscopy detects neuropathy in patients with type 1 diabetes without retinopathy or microalbuminuria.

AU - Petropoulos, Ioannis N

AU - Green, Patrick

AU - Chan, Agnes W S

AU - Alam, Uazman

AU - Fadavi, Hassan

AU - Marshall, Andrew

AU - Asghar, Omar

AU - Efron, Nathan

AU - Tavakoli, Mitra

AU - Malik, Rayaz

N1 - R105991, PHS HHS, United States

PY - 2015

Y1 - 2015

N2 - OBJECTIVE: Corneal innervation is increasingly used as a surrogate marker of human diabetic peripheral neuropathy (DPN) however its temporal relationship with the other microvascular complications of diabetes is not fully established. In this cross-sectional, observational study we aimed to assess whether neuropathy occurred in patients with type 1 diabetes, without retinopathy or microalbuminuria. MATERIALS AND METHODS: All participants underwent detailed assessment of peripheral neuropathy [neuropathy disability score (NDS), vibration perception threshold (VPT), peroneal motor nerve conduction velocity (PMNCV), sural sensory nerve conduction velocity (SSNCV) and in vivo corneal confocal microscopy (IVCCM)], retinopathy (digital fundus photography) and albuminuria status [albumin: creatinine ratio (ACR)]. RESULTS: 53 patients with Type 1 diabetes with (n=37) and without retinopathy (n=16) were compared to control subjects (n=27). SSNCV, corneal nerve fibre (CNFD) and branch (CNBD) density and length (CNFL) were reduced significantly (p

AB - OBJECTIVE: Corneal innervation is increasingly used as a surrogate marker of human diabetic peripheral neuropathy (DPN) however its temporal relationship with the other microvascular complications of diabetes is not fully established. In this cross-sectional, observational study we aimed to assess whether neuropathy occurred in patients with type 1 diabetes, without retinopathy or microalbuminuria. MATERIALS AND METHODS: All participants underwent detailed assessment of peripheral neuropathy [neuropathy disability score (NDS), vibration perception threshold (VPT), peroneal motor nerve conduction velocity (PMNCV), sural sensory nerve conduction velocity (SSNCV) and in vivo corneal confocal microscopy (IVCCM)], retinopathy (digital fundus photography) and albuminuria status [albumin: creatinine ratio (ACR)]. RESULTS: 53 patients with Type 1 diabetes with (n=37) and without retinopathy (n=16) were compared to control subjects (n=27). SSNCV, corneal nerve fibre (CNFD) and branch (CNBD) density and length (CNFL) were reduced significantly (p

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DO - 10.1371/journal.pone.0123517

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VL - 10

JO - PLoS ONE

JF - PLoS ONE

IS - 4

ER -

Corneal confocal microscopy detects neuropathy in patients with type 1 diabetes without retinopathy or microalbuminuria.

Abstract

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Projects

ENA: Early Neuropathy Assessment (ENA)

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