Corneal sensitivity is related to established measures of diabetic peripheral neuropathy

Nicola Pritchard, Katie Edwards, Dimitrios Vagenas, Anthony W Russell, Rayaz A Malik, Nathan Efron

Research output: Contribution to journalArticlepeer-review

Abstract

PURPOSE: The objective was to investigate the association between corneal sensitivity and established measures of diabetic peripheral neuropathy (DPN).

METHODS: Corneal sensitivity was measured in 93 individuals with diabetes, 146 diabetic individuals without neuropathy and 61 control individuals without diabetes or neuropathy using a non-contact corneal aesthesiometer at the baseline visit of a five-year longitudinal natural history study of DPN. The correlation between corneal sensitivity and established measures of neuropathy was estimated and multi-dimensional scaling was used to represent similarities and dissimilarities between variables.

RESULTS: The corneal sensitivity threshold was significantly correlated with a majority of established measures of DPN. Correlation coefficients ranged from -0.32 to 0.26. Using multi-dimensional scaling, non-contact corneal aesthesiometry was closer to the neuropathy disability score, diabetic neuropathy symptom score and Neuropad and most dissimilar to electrophysiological parameters and quantitative sensory testing.

CONCLUSION: Corneal sensitivity, although not strongly related, is associated with other functional measures of DPN and might provide a useful adjunct in identifying functional loss of small nerve fibre integrity.

Original languageEnglish
Pages (from-to)355-61
Number of pages7
JournalClinical & experimental optometry
Volume95
Issue number3
DOIs
Publication statusPublished - May 2012

Keywords

  • Adult
  • Aged
  • Cornea
  • Diabetic Neuropathies
  • Humans
  • Middle Aged
  • Nerve Fibers
  • Journal Article
  • Research Support, Non-U.S. Gov't

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