Corpus callosal atrophy in premanifest and early Huntington's disease.

Helen E Crawford, Nicola Z Hobbs, Ruth Keogh, Douglas R Langbehn, Chris Frost, Hans Johnson, Bernhard Landwehrmeyer, Ralf Reilmann, David Craufurd, Julie C Stout, Alexandra Durr, Blair R Leavitt, Raymund A C Roos, Sarah J Tabrizi, Rachael I Scahill, Natalie Arran (Collaborator), Eric Axelson (Collaborator), Natalie Bechtel (Collaborator), Simon J A van den Bogaard (Collaborator), Jenny Callaghan (Collaborator)Stefan Bohlen (Collaborator), Colin Campbell (Collaborator), Melissa Campbell (Collaborator), David M Cash (Collaborator), Allison Coleman (Collaborator), Rachelle Dar Santos (Collaborator), Joji Decolongon (Collaborator), Eve M Dumas (Collaborator), Nick C Fox (Collaborator), Jeroen van der Grond (Collaborator), Ellen P Hart (Collaborator), Celine Jauffret (Collaborator), Rebecca Jones (Collaborator), Damian Justo (Collaborator), Nayana Lahiri (Collaborator), Stéphane Lehericy (Collaborator), Ian Malone (Collaborator), Cecilia Marelli (Collaborator), Cassie Milchman (Collaborator), Kevin Nigaud (Collaborator), Sarah Queller (Collaborator), Joy Read (Collaborator), Miranda J Say (Collaborator), Cheryl Stopford (Collaborator), Aaron Sturrock (Collaborator), Romain Vallabrègue (Collaborator), Edward Wild (Collaborator)

    Research output: Contribution to journalArticlepeer-review


    BACKGROUND: Volumetric MRI studies have highlighted the pronounced loss of white matter in premanifest and early Huntington's Disease (HD). The current study focussed on the corpus callosum (CC) since it provides interhemispheric connections to vulnerable cortical areas. OBJECTIVES: To investigate cross-sectional and longitudinal group differences in CC volume and hypothesis-driven associations with three cognitive tasks. METHODS: Baseline and 24-month 3T MRI were analysed from 106 premanifest (PreHD), (59 preHD-A ≥10.8 and 47 preHD-B
    Original languageEnglish
    JournalJournal of Huntington's disease
    Issue number4
    Publication statusPublished - 2013


    • Huntington's disease
    • MRI
    • atrophy
    • corpus callosum


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