Corpus callosal atrophy in premanifest and early Huntington's disease.

Helen E Crawford; Nicola Z Hobbs; Ruth Keogh; Douglas R Langbehn; Chris Frost; Hans Johnson; Bernhard Landwehrmeyer; Ralf Reilmann; David Craufurd; Julie C Stout; Alexandra Durr; Blair R Leavitt; Raymund A C Roos; Sarah J Tabrizi; Rachael I Scahill; Natalie Arran; Eric Axelson; Natalie Bechtel; Simon J A van den Bogaard; Jenny Callaghan; Stefan Bohlen; Colin Campbell; Melissa Campbell; David M Cash; Allison Coleman; Rachelle Dar Santos; Joji Decolongon; Eve M Dumas; Nick C Fox; Jeroen van der Grond; Ellen P Hart; Celine Jauffret; Rebecca Jones; Damian Justo; Nayana Lahiri; Stéphane Lehericy; Ian Malone; Cecilia Marelli; Cassie Milchman; Kevin Nigaud; Sarah Queller; Joy Read; Miranda J Say; Cheryl Stopford; Aaron Sturrock; Romain Vallabrègue; Edward Wild

doi:10.3233/JHD-130077

Corpus callosal atrophy in premanifest and early Huntington's disease.

Helen E Crawford, Nicola Z Hobbs, Ruth Keogh, Douglas R Langbehn, Chris Frost, Hans Johnson, Bernhard Landwehrmeyer, Ralf Reilmann, David Craufurd, Julie C Stout, Alexandra Durr, Blair R Leavitt, Raymund A C Roos, Sarah J Tabrizi, Rachael I Scahill, Natalie Arran (Collaborator), Eric Axelson (Collaborator), Natalie Bechtel (Collaborator), Simon J A van den Bogaard (Collaborator), Jenny Callaghan (Collaborator)Stefan Bohlen (Collaborator), Colin Campbell (Collaborator), Melissa Campbell (Collaborator), David M Cash (Collaborator), Allison Coleman (Collaborator), Rachelle Dar Santos (Collaborator), Joji Decolongon (Collaborator), Eve M Dumas (Collaborator), Nick C Fox (Collaborator), Jeroen van der Grond (Collaborator), Ellen P Hart (Collaborator), Celine Jauffret (Collaborator), Rebecca Jones (Collaborator), Damian Justo (Collaborator), Nayana Lahiri (Collaborator), Stéphane Lehericy (Collaborator), Ian Malone (Collaborator), Cecilia Marelli (Collaborator), Cassie Milchman (Collaborator), Kevin Nigaud (Collaborator), Sarah Queller (Collaborator), Joy Read (Collaborator), Miranda J Say (Collaborator), Cheryl Stopford (Collaborator), Aaron Sturrock (Collaborator), Romain Vallabrègue (Collaborator), Edward Wild (Collaborator)

Research output: Contribution to journal › Article › peer-review

Abstract

BACKGROUND: Volumetric MRI studies have highlighted the pronounced loss of white matter in premanifest and early Huntington's Disease (HD). The current study focussed on the corpus callosum (CC) since it provides interhemispheric connections to vulnerable cortical areas. OBJECTIVES: To investigate cross-sectional and longitudinal group differences in CC volume and hypothesis-driven associations with three cognitive tasks. METHODS: Baseline and 24-month 3T MRI were analysed from 106 premanifest (PreHD), (59 preHD-A ≥10.8 and 47 preHD-B

Original language	English
Journal	Journal of Huntington's disease
Volume	2
Issue number	4
DOIs	https://doi.org/10.3233/JHD-130077
Publication status	Published - 2013

Keywords

Huntington's disease
MRI
atrophy
corpus callosum

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10.3233/JHD-130077

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Crawford, H. E., Hobbs, N. Z., Keogh, R., Langbehn, D. R., Frost, C., Johnson, H., Landwehrmeyer, B., Reilmann, R., Craufurd, D., Stout, J. C., Durr, A., Leavitt, B. R., Roos, R. A. C., Tabrizi, S. J., Scahill, R. I., Arran, N., Axelson, E., Bechtel, N., van den Bogaard, S. J. A., ... Wild, E. (2013). Corpus callosal atrophy in premanifest and early Huntington's disease. Journal of Huntington's disease, 2(4). https://doi.org/10.3233/JHD-130077

@article{e8e670e10b09445ebb302429179d5fcb,

title = "Corpus callosal atrophy in premanifest and early Huntington's disease.",

abstract = "BACKGROUND: Volumetric MRI studies have highlighted the pronounced loss of white matter in premanifest and early Huntington's Disease (HD). The current study focussed on the corpus callosum (CC) since it provides interhemispheric connections to vulnerable cortical areas. OBJECTIVES: To investigate cross-sectional and longitudinal group differences in CC volume and hypothesis-driven associations with three cognitive tasks. METHODS: Baseline and 24-month 3T MRI were analysed from 106 premanifest (PreHD), (59 preHD-A ≥10.8 and 47 preHD-B",

keywords = "Huntington's disease, MRI, atrophy, corpus callosum",

author = "Crawford, {Helen E} and Hobbs, {Nicola Z} and Ruth Keogh and Langbehn, {Douglas R} and Chris Frost and Hans Johnson and Bernhard Landwehrmeyer and Ralf Reilmann and David Craufurd and Stout, {Julie C} and Alexandra Durr and Leavitt, {Blair R} and Roos, {Raymund A C} and Tabrizi, {Sarah J} and Scahill, {Rachael I} and Natalie Arran and Eric Axelson and Natalie Bechtel and {van den Bogaard}, {Simon J A} and Jenny Callaghan and Stefan Bohlen and Colin Campbell and Melissa Campbell and Cash, {David M} and Allison Coleman and {Dar Santos}, Rachelle and Joji Decolongon and Dumas, {Eve M} and Fox, {Nick C} and {van der Grond}, Jeroen and Hart, {Ellen P} and Celine Jauffret and Rebecca Jones and Damian Justo and Nayana Lahiri and St{\'e}phane Lehericy and Ian Malone and Cecilia Marelli and Cassie Milchman and Kevin Nigaud and Sarah Queller and Joy Read and Say, {Miranda J} and Cheryl Stopford and Aaron Sturrock and Romain Vallabr{\`e}gue and Edward Wild",

year = "2013",

doi = "10.3233/JHD-130077",

language = "English",

volume = "2",

journal = "Journal of Huntington's disease",

issn = "1879-6397",

publisher = "IOS Press",

number = "4",

}

Crawford, HE, Hobbs, NZ, Keogh, R, Langbehn, DR, Frost, C, Johnson, H, Landwehrmeyer, B, Reilmann, R, Craufurd, D, Stout, JC, Durr, A, Leavitt, BR, Roos, RAC, Tabrizi, SJ, Scahill, RI, Arran, N, Axelson, E, Bechtel, N, van den Bogaard, SJA, Callaghan, J, Bohlen, S, Campbell, C, Campbell, M, Cash, DM, Coleman, A, Dar Santos, R, Decolongon, J, Dumas, EM, Fox, NC, van der Grond, J, Hart, EP, Jauffret, C, Jones, R, Justo, D, Lahiri, N, Lehericy, S, Malone, I, Marelli, C, Milchman, C, Nigaud, K, Queller, S, Read, J, Say, MJ, Stopford, C, Sturrock, A, Vallabrègue, R & Wild, E 2013, 'Corpus callosal atrophy in premanifest and early Huntington's disease.', Journal of Huntington's disease, vol. 2, no. 4. https://doi.org/10.3233/JHD-130077

TY - JOUR

T1 - Corpus callosal atrophy in premanifest and early Huntington's disease.

AU - Crawford, Helen E

AU - Hobbs, Nicola Z

AU - Keogh, Ruth

AU - Langbehn, Douglas R

AU - Frost, Chris

AU - Johnson, Hans

AU - Landwehrmeyer, Bernhard

AU - Reilmann, Ralf

AU - Craufurd, David

AU - Stout, Julie C

AU - Durr, Alexandra

AU - Leavitt, Blair R

AU - Roos, Raymund A C

AU - Tabrizi, Sarah J

AU - Scahill, Rachael I

A2 - Arran, Natalie

A2 - Axelson, Eric

A2 - Bechtel, Natalie

A2 - van den Bogaard, Simon J A

A2 - Callaghan, Jenny

A2 - Bohlen, Stefan

A2 - Campbell, Colin

A2 - Campbell, Melissa

A2 - Cash, David M

A2 - Coleman, Allison

A2 - Dar Santos, Rachelle

A2 - Decolongon, Joji

A2 - Dumas, Eve M

A2 - Fox, Nick C

A2 - van der Grond, Jeroen

A2 - Hart, Ellen P

A2 - Jauffret, Celine

A2 - Jones, Rebecca

A2 - Justo, Damian

A2 - Lahiri, Nayana

A2 - Lehericy, Stéphane

A2 - Malone, Ian

A2 - Marelli, Cecilia

A2 - Milchman, Cassie

A2 - Nigaud, Kevin

A2 - Queller, Sarah

A2 - Read, Joy

A2 - Say, Miranda J

A2 - Stopford, Cheryl

A2 - Sturrock, Aaron

A2 - Vallabrègue, Romain

A2 - Wild, Edward

PY - 2013

Y1 - 2013

N2 - BACKGROUND: Volumetric MRI studies have highlighted the pronounced loss of white matter in premanifest and early Huntington's Disease (HD). The current study focussed on the corpus callosum (CC) since it provides interhemispheric connections to vulnerable cortical areas. OBJECTIVES: To investigate cross-sectional and longitudinal group differences in CC volume and hypothesis-driven associations with three cognitive tasks. METHODS: Baseline and 24-month 3T MRI were analysed from 106 premanifest (PreHD), (59 preHD-A ≥10.8 and 47 preHD-B

AB - BACKGROUND: Volumetric MRI studies have highlighted the pronounced loss of white matter in premanifest and early Huntington's Disease (HD). The current study focussed on the corpus callosum (CC) since it provides interhemispheric connections to vulnerable cortical areas. OBJECTIVES: To investigate cross-sectional and longitudinal group differences in CC volume and hypothesis-driven associations with three cognitive tasks. METHODS: Baseline and 24-month 3T MRI were analysed from 106 premanifest (PreHD), (59 preHD-A ≥10.8 and 47 preHD-B

KW - Huntington's disease

KW - MRI

KW - atrophy

KW - corpus callosum

U2 - 10.3233/JHD-130077

DO - 10.3233/JHD-130077

M3 - Article

C2 - 25062736

SN - 1879-6397

VL - 2

JO - Journal of Huntington's disease

JF - Journal of Huntington's disease

IS - 4

ER -

Corpus callosal atrophy in premanifest and early Huntington's disease.

Abstract

Keywords

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