Correlation between in vitro growth rate and in vivo virulence in Aspergillus fumigatus

Derek Paisley; Geoffrey D. Robson; David W. Denning

doi:10.1080/13693780400005866

Correlation between in vitro growth rate and in vivo virulence in Aspergillus fumigatus

Derek Paisley, Geoffrey D. Robson, David W. Denning

Research output: Contribution to journal › Article › peer-review

Abstract

We describe a kinetic microbroth method of measuring the growth rate of Aspergillus fumigatus spectrophotometrically. Using this method, growth rates were determined for nine A. fumigatus isolates for which an LD90 value in immunosuppressed CD-1 mice had previously been obtained. Comparison of the growth rates and LD90 values of these isolates suggests that a correlation exists between the two parameters. © 2005 ISHAM.

Original language	English
Pages (from-to)	397-401
Number of pages	4
Journal	Medical Mycology
Volume	43
Issue number	5
DOIs	https://doi.org/10.1080/13693780400005866
Publication status	Published - Aug 2005

Keywords

Amphotericin
Fitness
Genome
Resistance

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10.1080/13693780400005866

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title = "Correlation between in vitro growth rate and in vivo virulence in Aspergillus fumigatus",

abstract = "We describe a kinetic microbroth method of measuring the growth rate of Aspergillus fumigatus spectrophotometrically. Using this method, growth rates were determined for nine A. fumigatus isolates for which an LD90 value in immunosuppressed CD-1 mice had previously been obtained. Comparison of the growth rates and LD90 values of these isolates suggests that a correlation exists between the two parameters. {\textcopyright} 2005 ISHAM.",

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year = "2005",

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AU - Paisley, Derek

AU - Robson, Geoffrey D.

AU - Denning, David W.

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N2 - We describe a kinetic microbroth method of measuring the growth rate of Aspergillus fumigatus spectrophotometrically. Using this method, growth rates were determined for nine A. fumigatus isolates for which an LD90 value in immunosuppressed CD-1 mice had previously been obtained. Comparison of the growth rates and LD90 values of these isolates suggests that a correlation exists between the two parameters. © 2005 ISHAM.

AB - We describe a kinetic microbroth method of measuring the growth rate of Aspergillus fumigatus spectrophotometrically. Using this method, growth rates were determined for nine A. fumigatus isolates for which an LD90 value in immunosuppressed CD-1 mice had previously been obtained. Comparison of the growth rates and LD90 values of these isolates suggests that a correlation exists between the two parameters. © 2005 ISHAM.

KW - Amphotericin

KW - Fitness

KW - Genome

KW - Resistance

U2 - 10.1080/13693780400005866

DO - 10.1080/13693780400005866

M3 - Article

SN - 1369-3786

VL - 43

SP - 397

EP - 401

JO - Medical Mycology

JF - Medical Mycology

IS - 5

ER -

Correlation between in vitro growth rate and in vivo virulence in Aspergillus fumigatus

Abstract

Keywords

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