Correlation of interleukin-6 serum levels with bone density in postmenopausal women

N. G. Papadopoulos; K. Georganas; V. Skoutellas; E. Konstantellos; G. P. Lyritis

Correlation of interleukin-6 serum levels with bone density in postmenopausal women

N. G. Papadopoulos, K. Georganas, V. Skoutellas, E. Konstantellos, G. P. Lyritis

Research output: Contribution to journal › Article › peer-review

Abstract

In order to identify possible correlations between interleukin-6 (IL-6) and hormonal and biochemical parameters of bone metabolism, or bone density, 24 postmenopausal women were studied. Serum IL-6, estradiol, calcium, phosphorus, osteocalcin, alkaline phosphatase, the urinary secretion of calcium, phosphorus and hydroxyproline, and bone density of the lumbar spine, femur and radius were measured. No significant correlation was found between IL-6 and the biochemical parameters. A negative correlation was found between IL-6 and serum estradiol, as well as between IL-6 and bone density in 5 out of 6 sites studied. It is possible that women with high IL-6 levels, may develop lower bone mass.

Original language	English
Pages (from-to)	162-165
Number of pages	3
Journal	Clinical Rheumatology
Volume	16
Issue number	2
Publication status	Published - Mar 1997

Keywords

Bone density
Bone markers
Cytokines
Interleukin-6
Osteoporosis

Cite this

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title = "Correlation of interleukin-6 serum levels with bone density in postmenopausal women",

abstract = "In order to identify possible correlations between interleukin-6 (IL-6) and hormonal and biochemical parameters of bone metabolism, or bone density, 24 postmenopausal women were studied. Serum IL-6, estradiol, calcium, phosphorus, osteocalcin, alkaline phosphatase, the urinary secretion of calcium, phosphorus and hydroxyproline, and bone density of the lumbar spine, femur and radius were measured. No significant correlation was found between IL-6 and the biochemical parameters. A negative correlation was found between IL-6 and serum estradiol, as well as between IL-6 and bone density in 5 out of 6 sites studied. It is possible that women with high IL-6 levels, may develop lower bone mass.",

keywords = "Bone density, Bone markers, Cytokines, Interleukin-6, Osteoporosis",

author = "Papadopoulos, {N. G.} and K. Georganas and V. Skoutellas and E. Konstantellos and Lyritis, {G. P.}",

year = "1997",

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language = "English",

volume = "16",

pages = "162--165",

journal = "Clinical Rheumatology",

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T1 - Correlation of interleukin-6 serum levels with bone density in postmenopausal women

AU - Papadopoulos, N. G.

AU - Georganas, K.

AU - Skoutellas, V.

AU - Konstantellos, E.

AU - Lyritis, G. P.

PY - 1997/3

Y1 - 1997/3

N2 - In order to identify possible correlations between interleukin-6 (IL-6) and hormonal and biochemical parameters of bone metabolism, or bone density, 24 postmenopausal women were studied. Serum IL-6, estradiol, calcium, phosphorus, osteocalcin, alkaline phosphatase, the urinary secretion of calcium, phosphorus and hydroxyproline, and bone density of the lumbar spine, femur and radius were measured. No significant correlation was found between IL-6 and the biochemical parameters. A negative correlation was found between IL-6 and serum estradiol, as well as between IL-6 and bone density in 5 out of 6 sites studied. It is possible that women with high IL-6 levels, may develop lower bone mass.

AB - In order to identify possible correlations between interleukin-6 (IL-6) and hormonal and biochemical parameters of bone metabolism, or bone density, 24 postmenopausal women were studied. Serum IL-6, estradiol, calcium, phosphorus, osteocalcin, alkaline phosphatase, the urinary secretion of calcium, phosphorus and hydroxyproline, and bone density of the lumbar spine, femur and radius were measured. No significant correlation was found between IL-6 and the biochemical parameters. A negative correlation was found between IL-6 and serum estradiol, as well as between IL-6 and bone density in 5 out of 6 sites studied. It is possible that women with high IL-6 levels, may develop lower bone mass.

KW - Bone density

KW - Bone markers

KW - Cytokines

KW - Interleukin-6

KW - Osteoporosis

M3 - Article

C2 - 9093798

SN - 0770-3198

VL - 16

SP - 162

EP - 165

JO - Clinical Rheumatology

JF - Clinical Rheumatology

IS - 2

ER -

Correlation of interleukin-6 serum levels with bone density in postmenopausal women

Abstract

Keywords

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