Projects per year
Abstract
Research on graphene based nanomaterials has flourished in the last decade due their unique properties and emerging socio-economic impact. In the context of their potential exploitation for biomedical applications, there is a growing need for the development of more efficient imaging techniques to track the fate of these materials. Herein we propose the first correlative imaging approach based on the combination of radioimaging and mass spectrometry imaging for the detection of Graphene Oxide (GO) labelled with carbon-14 in mice. In this study, 14C-graphene oxide nanoribbons were produced from the oxidative opening of 14C-carbon nanotubes, and were then intensively sonicated to provide nano-size 14C-GO flakes. After Intravenous administration in mice, 14C-GO distribution was quantified by radioimaging performed on tissue slices. On the same slices, MS-imaging provided a highly resolved distribution map of the nanomaterial based on the detection of specific radical anionic carbon clusters ranging from C2˙− to C9˙− with a base peak at m/z 72 (12C) and 74 (14C) under negative laser desorption ionization mass spectrometry (LDI-MS) conditions. This proof of concept approach synergizes the strength of each technique and could be advantageous in the pre-clinical development of future Graphene-based biomedical applications.
Original language | English |
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Pages (from-to) | 5510-5518 |
Number of pages | 8 |
Journal | Nanoscale |
Volume | 15 |
Issue number | 11 |
Early online date | 20 Feb 2023 |
DOIs | |
Publication status | Published - 20 Feb 2023 |
Keywords
- graphene
- biodistribution
- imaging
Research Beacons, Institutes and Platforms
- Advanced materials
- Christabel Pankhurst Institute
- National Graphene Institute
Fingerprint
Dive into the research topics of 'Correlative radioimaging and mass spectrometry imaging: a powerful combination to study 14C-graphene oxide in vivo biodistribution'. Together they form a unique fingerprint.Projects
- 2 Finished
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Graphene Flagship Core 3
Kostarelos, K. (PI), Bussy, C. (CoI), Coope, D. (CoI) & Vranic, S. (CoI)
1/04/20 → 30/09/23
Project: Research
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Understanding the health limitations for a safe use of graphene and 2D materials.
Bussy, C. (PI)
1/04/18 → 31/03/21
Project: Other
Research output
- 4 Article
-
Pulmonary toxicity of boron nitride nanomaterials is aspect ratio dependent
Visani de Luna, L. A., Loret, T., He, Y., Legnani, M., Lin, H., Galibert, A. M., Fordham, A., Holme, S., del Rio Castillo, A. E., Bonaccorso, F., Bianco, A., Flahaut, E., Kostarelos, K. & Bussy, C., 26 Dec 2023, In: ACS Nano. 17, 24, p. 24919-24935Research output: Contribution to journal › Article › peer-review
Open Access -
Lung recovery from DNA damage induced by graphene oxide is dependent on size, dose and inflammation profile
de Luna, L. A. V., Loret, T., Fordham, A., Arshad, A., Drummond, M., Dodd, A., Lozano, N., Kostarelos, K. & Bussy, C., 21 Sept 2022, In: Particle and Fibre Toxicology. 19, 1, 62.Research output: Contribution to journal › Article › peer-review
Open Access -
Safety Assessment of Graphene-Based Materials: Focus on Human Health and the Environment
Fadeel, B., Bussy, C., Merino, S., Vázquez, E., Flahaut, E., Mouchet, F., Evariste, L., Gauthier, L., Koivisto, A. J., Vogel, U., Martin, C., Delogu, L. G., Bürki-Thurnherr, T., Wick, P., Beloin-Saint-Pierre, D., Hischier, R., Pelin, M., Candotto Carniel, F., Tretiach, M. & Cesca, F. & 6 others, , 2018, In: ACS Nano.Research output: Contribution to journal › Article › peer-review
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