Cortical and subcortical control of tongue movement in humans: A functional neuroimaging study using fMRI

Douglas Corfield, D. R. Corfield, K. Murphy, O. Josephs, G. R. Fink, R. S J Frackowiak, A. Guz, L. Adams, R. Turner

    Research output: Contribution to journalArticlepeer-review


    We have used voluntary tongue contraction to test whether we can image activation of the hypoglossal nuclei within the human brain stem by using functional magnetic resonance imaging (fMRI). Functional images of the whole brain were acquired in eight subjects by using T2-weighted echo planar imaging (blood oxygen level development) every 6.2 s. Sequences of images were acquired during 12 periods of 31-s 'isometric' rhythmic tongue contraction alternated with 12 periods of 31-s tongue relaxation. Noise arising from cardiac- and respiratory-related movement was removed either by filtration (high pass cutoff 120 s) or by inclusion in the statistical analysis as confounding effects of no interest. For the group, tongue contraction was associated with significant signal increases (P <0.05 corrected for multiple comparisons) in the sensorimotor cortex, supplementary motor area, operculum, insula, thalamus, and cerebellum. For the group and for six of eight individuals, significant signal increases were also seen within the medulla (P <0.001, predefined region of interest with no correction for multiple comparisons) this signal is most likely to reflect neuronal activation associated with the hypoglossal motor nuclei. The data demonstrate that fMRI can be used to detect, simultaneously, the cerebral and brain stem control of tongue movement.
    Original languageEnglish
    Pages (from-to)1468-1477
    Number of pages9
    JournalJournal of Applied Physiology
    Issue number5
    Publication statusPublished - May 1999


    • Functional magnetic resonance imaging
    • Genioglossus
    • Hypoglossal nucleus
    • Medulla


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