Cortical serotonin receptor subtypes after lesion of ascending cholinergic neurones in rat

Alan Cross, J F Deakin

Research output: Contribution to journalArticlepeer-review

Abstract

Serotonin (5-HT) S1 and S2 receptors were studied in rat cortex after lesion of the ascending cholinergic systems by injection of ibotenic acid into the nucleus basalis. The lesions produced a large (56%) decrease in choline acetyltransferase activity with no change in markers of gamma-aminobutyric acid, dopamine and 5-HT containing neurones. Lesions of the ascending cholinergic neurones were accompanied by a loss of 5-HT S1 receptor binding sites with no change in S2 receptors. These results suggest that a proportion of S1 receptors may be associated with cholinergic terminals.

Original languageEnglish
Pages (from-to)261-5
Number of pages5
JournalNeuroscience letters
Volume60
Issue number3
Publication statusPublished - 10 Oct 1985

Keywords

  • Animals
  • Basal Ganglia
  • Brain Diseases
  • Cerebral Cortex
  • Choline O-Acetyltransferase
  • Cholinergic Fibers
  • Ibotenic Acid
  • Male
  • Rats
  • Rats, Inbred Strains
  • Receptors, Serotonin
  • Substantia Innominata
  • Journal Article

Fingerprint

Dive into the research topics of 'Cortical serotonin receptor subtypes after lesion of ascending cholinergic neurones in rat'. Together they form a unique fingerprint.

Cite this