Corticotrophin-releasing factor and urocortin inhibit system a activity in term human placental villous explants

A. Giovannelli, S. L. Greenwood, M. Desforges, C. P. Sibley, F. Petraglia

Research output: Contribution to journalArticlepeer-review

Abstract

Plasma corticotrophin-releasing factor (CRF) and urocortin are elevated in preterm labour and/or fetal growth restriction (FGR). FGR is associated with reduced placental system A amino acid transporter activity and in vitro data suggest altered endocrine status could be responsible. Here we test the hypothesis that CRF and urocortin inhibit placental system A activity. Chronic (48 h) exposure of term placental villous explants to these hormones (10 -7 M) significantly reduced system A activity (Na+- dependent 14C-methylaminoisobutyric acid uptake), whereas 1 h exposure had no effect. We propose elevated CRF and urocortin contribute to FGR through negative regulation of placental system A activity. © 2010 Elsevier Ltd. All rights reserved.
Original languageEnglish
Pages (from-to)99-101
Number of pages2
JournalPlacenta
Volume32
Issue number1
DOIs
Publication statusPublished - Jan 2011

Keywords

  • Hormones
  • MeAIB
  • SNAT
  • Syncytiotrophoblast

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