CoSec: a hub of online tools for comparing secondary structure elements

A common problem with in-silico protein modelling is choosing the best model out of a cluster of protein models suggested by the online servers. Besides identifying a right model based on torsion angles and potentials, a lot of researchers look at the model that retains most of its predicted secondary structures. The comparison of the secondary structure elements at residue level becomes more tedious as the size of the protein increases. So, we have developed two tools predicted secondary structure matching (PreSSM) and compare assigned secondary structure (CompASS) under one umbrella CoSec. PreSSM compares the secondary structure elements of a modelled protein from a PDB to the secondary structure predicted, while CompASS compares the secondary structures between two PDBs of the same protein (typically the models before and after simulation/docking with a ligand/mutation). Moreover, the two tools use STRIDE (with 95% consensus, with 5% divergence) to assign secondary structure confirmation to residues in the given protein's structure.