COVID-19 in children with haematological malignancies

Gerard Cathal Millen; Roland Arnold; Jean-Baptiste Cazier; Helen Curley; Richard Feltbower; Ashley Gamble; Adam Glaser; Richard G Grundy; Laura Kirton; Lennard Y W Lee; Martin G McCabe; Claire Palles; Bob Phillips; Charles A Stiller; Csilla Varnai; Pamela Kearns

doi:10.1136/archdischild-2021-322062

COVID-19 in children with haematological malignancies

Gerard Cathal Millen, Roland Arnold, Jean-Baptiste Cazier, Helen Curley, Richard Feltbower, Ashley Gamble, Adam Glaser, Richard G Grundy, Laura Kirton, Lennard Y W Lee, Martin G McCabe, Claire Palles, Bob Phillips, Charles A Stiller, Csilla Varnai, Pamela Kearns

Division of Cancer Sciences (L5)

Research output: Contribution to journal › Article › peer-review

Abstract

BACKGROUND: Children with cancer are not at increased risk of severe SARS-CoV-2 infection; however, adults with haematological malignancies have increased risk of severe infections compared with non-haematological malignancies.

METHODS: We compared patients with haematological and non-haematological malignancies enrolled in the UK Paediatric Coronavirus Cancer Monitoring Project between 12 March 2020 and 16 February 2021. Children who received stem cell transplantation were excluded.

RESULTS: Only 2/62 patients with haematological malignancy had severe/critical infections, with an OR of 0.5 for patients with haematological compared with non-haematological malignancies.

INTERPRETATION: Children with haematological malignancies are at no greater risk of severe SARS-CoV-2 infection than those with non-haematological malignancies.

Original language	English
Pages (from-to)	186-188
Number of pages	3
Journal	Archives of Disease in Childhood
Volume	107
Issue number	2
Early online date	22 Jul 2021
DOIs	https://doi.org/10.1136/archdischild-2021-322062
Publication status	Published - 1 Feb 2022

Keywords

Adolescent
COVID-19/diagnosis
Child
Child, Preschool
Cohort Studies
Female
Hematologic Neoplasms/epidemiology
Humans
Infant
Male
Risk Assessment/statistics & numerical data
Risk Factors
SARS-CoV-2/immunology
Severity of Illness Index

Research Beacons, Institutes and Platforms

Manchester Cancer Research Centre

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1136/archdischild-2021-322062

Cite this

Millen, G. C., Arnold, R., Cazier, J.-B., Curley, H., Feltbower, R., Gamble, A., Glaser, A., Grundy, R. G., Kirton, L., Lee, L. Y. W., McCabe, M. G., Palles, C., Phillips, B., Stiller, C. A., Varnai, C., & Kearns, P. (2022). COVID-19 in children with haematological malignancies. Archives of Disease in Childhood, 107(2), 186-188. https://doi.org/10.1136/archdischild-2021-322062

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abstract = "BACKGROUND: Children with cancer are not at increased risk of severe SARS-CoV-2 infection; however, adults with haematological malignancies have increased risk of severe infections compared with non-haematological malignancies.METHODS: We compared patients with haematological and non-haematological malignancies enrolled in the UK Paediatric Coronavirus Cancer Monitoring Project between 12 March 2020 and 16 February 2021. Children who received stem cell transplantation were excluded.RESULTS: Only 2/62 patients with haematological malignancy had severe/critical infections, with an OR of 0.5 for patients with haematological compared with non-haematological malignancies.INTERPRETATION: Children with haematological malignancies are at no greater risk of severe SARS-CoV-2 infection than those with non-haematological malignancies.",

keywords = "Adolescent, COVID-19/diagnosis, Child, Child, Preschool, Cohort Studies, Female, Hematologic Neoplasms/epidemiology, Humans, Infant, Male, Risk Assessment/statistics & numerical data, Risk Factors, SARS-CoV-2/immunology, Severity of Illness Index",

author = "Millen, {Gerard Cathal} and Roland Arnold and Jean-Baptiste Cazier and Helen Curley and Richard Feltbower and Ashley Gamble and Adam Glaser and Grundy, {Richard G} and Laura Kirton and Lee, {Lennard Y W} and McCabe, {Martin G} and Claire Palles and Bob Phillips and Stiller, {Charles A} and Csilla Varnai and Pamela Kearns",

note = "Funding Information: University of Birmingham provided the database and bio-informatics support, GCM is partially funded by a Cancer Research UK grant (A30259). This paper presents independent research supported by the National Institute for Health Research (NIHR) Birmingham Biomedical Research Centre (Grant Reference Number BRC-1215-20009). Publisher Copyright: {\textcopyright}",

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doi = "10.1136/archdischild-2021-322062",

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AU - Millen, Gerard Cathal

AU - Arnold, Roland

AU - Cazier, Jean-Baptiste

AU - Curley, Helen

AU - Feltbower, Richard

AU - Gamble, Ashley

AU - Glaser, Adam

AU - Grundy, Richard G

AU - Kirton, Laura

AU - Lee, Lennard Y W

AU - McCabe, Martin G

AU - Palles, Claire

AU - Phillips, Bob

AU - Stiller, Charles A

AU - Varnai, Csilla

AU - Kearns, Pamela

N1 - Funding Information: University of Birmingham provided the database and bio-informatics support, GCM is partially funded by a Cancer Research UK grant (A30259). This paper presents independent research supported by the National Institute for Health Research (NIHR) Birmingham Biomedical Research Centre (Grant Reference Number BRC-1215-20009). Publisher Copyright: ©

PY - 2022/2/1

Y1 - 2022/2/1

N2 - BACKGROUND: Children with cancer are not at increased risk of severe SARS-CoV-2 infection; however, adults with haematological malignancies have increased risk of severe infections compared with non-haematological malignancies.METHODS: We compared patients with haematological and non-haematological malignancies enrolled in the UK Paediatric Coronavirus Cancer Monitoring Project between 12 March 2020 and 16 February 2021. Children who received stem cell transplantation were excluded.RESULTS: Only 2/62 patients with haematological malignancy had severe/critical infections, with an OR of 0.5 for patients with haematological compared with non-haematological malignancies.INTERPRETATION: Children with haematological malignancies are at no greater risk of severe SARS-CoV-2 infection than those with non-haematological malignancies.

AB - BACKGROUND: Children with cancer are not at increased risk of severe SARS-CoV-2 infection; however, adults with haematological malignancies have increased risk of severe infections compared with non-haematological malignancies.METHODS: We compared patients with haematological and non-haematological malignancies enrolled in the UK Paediatric Coronavirus Cancer Monitoring Project between 12 March 2020 and 16 February 2021. Children who received stem cell transplantation were excluded.RESULTS: Only 2/62 patients with haematological malignancy had severe/critical infections, with an OR of 0.5 for patients with haematological compared with non-haematological malignancies.INTERPRETATION: Children with haematological malignancies are at no greater risk of severe SARS-CoV-2 infection than those with non-haematological malignancies.

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KW - COVID-19/diagnosis

KW - Child

KW - Child, Preschool

KW - Cohort Studies

KW - Female

KW - Hematologic Neoplasms/epidemiology

KW - Humans

KW - Infant

KW - Male

KW - Risk Assessment/statistics & numerical data

KW - Risk Factors

KW - SARS-CoV-2/immunology

KW - Severity of Illness Index

U2 - 10.1136/archdischild-2021-322062

DO - 10.1136/archdischild-2021-322062

M3 - Article

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SN - 0003-9888

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SP - 186

EP - 188

JO - Archives of Disease in Childhood

JF - Archives of Disease in Childhood

IS - 2

ER -

COVID-19 in children with haematological malignancies

Abstract

Keywords

Research Beacons, Institutes and Platforms

UN SDGs

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