Criteria for assessing the neuroendocrine phenotype and its incidence in non-small cell lung cancers

H. E. Burnett; A. V. Spedding; N. Pendleton; W. E. Kenyon; C. Walker

doi:10.3892/ijo.3.1.65

Criteria for assessing the neuroendocrine phenotype and its incidence in non-small cell lung cancers

H. E. Burnett^*, A. V. Spedding, N. Pendleton, W. E. Kenyon, C. Walker

^*Corresponding author for this work

Division of Neuroscience

Clatterbridge Hospital

Research output: Contribution to journal › Article › peer-review

Abstract

The neuroendocrine (NE) characteristics of 26 resected non-small cell lung cancers (NSCLC) were determined using immunocytochemistry. All 26 tumours expressed some features of NE differentiation, but the percentage of NE- positive tumours varied when the criteria for positivity, such as minimum staining intensity and proportion of stained cells, were adjusted. The incidence of NE-NSCLC was higher in these tumours (up to 100%) compared to that found by other groups when using their criteria for NE positivity, suggesting a genuinely higher incidence of NE-NSCLC in this geographical region. NE phenotype in these tumours did not correlate with survival.

Original language	English
Pages (from-to)	65-69
Number of pages	5
Journal	International Journal of Oncology
Volume	3
Issue number	1
DOIs	https://doi.org/10.3892/ijo.3.1.65
Publication status	Published - 1 Jan 1993

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abstract = "The neuroendocrine (NE) characteristics of 26 resected non-small cell lung cancers (NSCLC) were determined using immunocytochemistry. All 26 tumours expressed some features of NE differentiation, but the percentage of NE- positive tumours varied when the criteria for positivity, such as minimum staining intensity and proportion of stained cells, were adjusted. The incidence of NE-NSCLC was higher in these tumours (up to 100%) compared to that found by other groups when using their criteria for NE positivity, suggesting a genuinely higher incidence of NE-NSCLC in this geographical region. NE phenotype in these tumours did not correlate with survival.",

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AU - Spedding, A. V.

AU - Pendleton, N.

AU - Kenyon, W. E.

AU - Walker, C.

PY - 1993/1/1

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AB - The neuroendocrine (NE) characteristics of 26 resected non-small cell lung cancers (NSCLC) were determined using immunocytochemistry. All 26 tumours expressed some features of NE differentiation, but the percentage of NE- positive tumours varied when the criteria for positivity, such as minimum staining intensity and proportion of stained cells, were adjusted. The incidence of NE-NSCLC was higher in these tumours (up to 100%) compared to that found by other groups when using their criteria for NE positivity, suggesting a genuinely higher incidence of NE-NSCLC in this geographical region. NE phenotype in these tumours did not correlate with survival.

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Criteria for assessing the neuroendocrine phenotype and its incidence in non-small cell lung cancers

Abstract

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