Crossing mice deficient in eNOS with placental-specific Igf2 knockout mice: A new model of fetal growth restriction

M. R. Dilworth; L. C. Kusinski; B. C. Baker; L. J. Renshall; P. N. Baker; S. L. Greenwood; M. Wareing; C. P. Sibley

doi:10.1016/j.placenta.2012.09.012

Crossing mice deficient in eNOS with placental-specific Igf2 knockout mice: A new model of fetal growth restriction

M. R. Dilworth, L. C. Kusinski, B. C. Baker, L. J. Renshall, P. N. Baker, S. L. Greenwood, M. Wareing, C. P. Sibley

Research output: Contribution to journal › Article › peer-review

Abstract

We tested the hypothesis that crossing two mouse models of fetal growth restriction (FGR) of differing phenotype would induce more severe FGR than either model alone. Female endothelial nitric oxide synthase knockout mice (eNOS-/-) were mated with placental-specific Igf2 knockout males (P0). Resultant fetuses were no more growth restricted than those with P0 deletion alone. However, P0 deletion attenuated the reduced placental system A amino acid transporter activity previously observed in eNOS-/- mice. Manipulating maternal and fetal genotypes provides a means to compare maternal and fetal regulation of fetal growth. © 2012 Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	1052-1054
Number of pages	2
Journal	Placenta
Volume	33
Issue number	12
Early online date	23 Oct 2012
DOIs	https://doi.org/10.1016/j.placenta.2012.09.012
Publication status	Published - Dec 2012

Keywords

FGR
Igf2
IUGR
Mouse
Placenta
Pregnancy

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10.1016/j.placenta.2012.09.012

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title = "Crossing mice deficient in eNOS with placental-specific Igf2 knockout mice: A new model of fetal growth restriction",

abstract = "We tested the hypothesis that crossing two mouse models of fetal growth restriction (FGR) of differing phenotype would induce more severe FGR than either model alone. Female endothelial nitric oxide synthase knockout mice (eNOS-/-) were mated with placental-specific Igf2 knockout males (P0). Resultant fetuses were no more growth restricted than those with P0 deletion alone. However, P0 deletion attenuated the reduced placental system A amino acid transporter activity previously observed in eNOS-/- mice. Manipulating maternal and fetal genotypes provides a means to compare maternal and fetal regulation of fetal growth. {\textcopyright} 2012 Elsevier Ltd. All rights reserved.",

keywords = "FGR, Igf2, IUGR, Mouse, Placenta, Pregnancy",

author = "Dilworth, {M. R.} and Kusinski, {L. C.} and Baker, {B. C.} and Renshall, {L. J.} and Baker, {P. N.} and Greenwood, {S. L.} and M. Wareing and Sibley, {C. P.}",

year = "2012",

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doi = "10.1016/j.placenta.2012.09.012",

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T1 - Crossing mice deficient in eNOS with placental-specific Igf2 knockout mice: A new model of fetal growth restriction

AU - Dilworth, M. R.

AU - Kusinski, L. C.

AU - Baker, B. C.

AU - Renshall, L. J.

AU - Baker, P. N.

AU - Greenwood, S. L.

AU - Wareing, M.

AU - Sibley, C. P.

PY - 2012/12

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N2 - We tested the hypothesis that crossing two mouse models of fetal growth restriction (FGR) of differing phenotype would induce more severe FGR than either model alone. Female endothelial nitric oxide synthase knockout mice (eNOS-/-) were mated with placental-specific Igf2 knockout males (P0). Resultant fetuses were no more growth restricted than those with P0 deletion alone. However, P0 deletion attenuated the reduced placental system A amino acid transporter activity previously observed in eNOS-/- mice. Manipulating maternal and fetal genotypes provides a means to compare maternal and fetal regulation of fetal growth. © 2012 Elsevier Ltd. All rights reserved.

AB - We tested the hypothesis that crossing two mouse models of fetal growth restriction (FGR) of differing phenotype would induce more severe FGR than either model alone. Female endothelial nitric oxide synthase knockout mice (eNOS-/-) were mated with placental-specific Igf2 knockout males (P0). Resultant fetuses were no more growth restricted than those with P0 deletion alone. However, P0 deletion attenuated the reduced placental system A amino acid transporter activity previously observed in eNOS-/- mice. Manipulating maternal and fetal genotypes provides a means to compare maternal and fetal regulation of fetal growth. © 2012 Elsevier Ltd. All rights reserved.

KW - FGR

KW - Igf2

KW - IUGR

KW - Mouse

KW - Placenta

KW - Pregnancy

U2 - 10.1016/j.placenta.2012.09.012

DO - 10.1016/j.placenta.2012.09.012

M3 - Article

C2 - 23099110

SN - 1532-3102

VL - 33

SP - 1052

EP - 1054

JO - Placenta

JF - Placenta

IS - 12

ER -

Crossing mice deficient in eNOS with placental-specific Igf2 knockout mice: A new model of fetal growth restriction

Abstract

Keywords

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