Cryptococcus neoformans var. grubii isolates recovered from persons with AIDS demonstrate a wide range of virulence during murine meningoencephalitis that correlates with the expression of certain virulence factors

Cornelius J. Clancy, M. Hong Nguyen, Ruth Alandoerffer, Shaoji Cheng, Kenneth Iczkowski, Malcolm Richardson, John R. Graybill

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Cryptococcus neoformans is a common cause of meningoencephalitis among AIDS patients. Several C. neoformans virulence factors have been identified, but the relative importance of particular factors is unknown. This study examined the corrrelation of the virulence of 18 C. neoformans var. grubii isolates from AIDS patients with the expression of several well-described virulence factors. The LD50 at 15 days after intracranial inoculation of ICR mice was 20 000 for 39 %. Higher cryptococcal concentrations in brains were noted for isolates with lower LD50 (P=0.002). In survival studies, no immunocompetent BALB/c mice (nu/-) infected with 3 × LD50 of three virulent isolates (LD50=62, 99, 1280) survived beyond 23 days, whereas 100 %, 90 % and 90 % of mice infected with 20 000 c.f.u. of three hypovirulent isolates (LD50>20 000) survived for 60 days (P
    Original languageEnglish
    Pages (from-to)2247-2255
    Number of pages8
    JournalMicrobiology
    Volume152
    Issue number8
    DOIs
    Publication statusPublished - Aug 2006

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