Crystallization in polymorphic systems: The solution-mediated transformation of β to α glycine

Elena S. Ferrari; Roger J. Davey; Wendy I. Cross; Amy L. Gillon; Christopher S. Towler

doi:10.1021/cg025561b

Crystallization in polymorphic systems: The solution-mediated transformation of β to α glycine

Elena S. Ferrari, Roger J. Davey, Wendy I. Cross, Amy L. Gillon, Christopher S. Towler

Research output: Contribution to journal › Article › peer-review

Abstract

The crystallization and subsequent polymorphic transformation from the β to the α form of glycine has been studied using optical microscopy, X-ray diffraction, and Fourier transform infrared spectroscopy techniques. The crystal structure and morphology of β glycine have been determined, and the influence of solvent, solubility, and process scale on its solvent-mediated transformation to the (α form was quantified. It is concluded that for the low solubility environments used in this study, the rate-determining step in the transformation process is the dissolution rate of the metastable β polymorph.

Original language	English
Pages (from-to)	53-60
Number of pages	7
Journal	Crystal Growth and Design
Volume	3
Issue number	1
DOIs	https://doi.org/10.1021/cg025561b
Publication status	Published - Jan 2003

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10.1021/cg025561b

CCDC 204200: Experimental Crystal Structure Determination
Ferrari, E. (Contributor), Davey, R. (Contributor), Cross, W. I. (Contributor), Gillon, A. L. (Contributor) & Towler, C. (Contributor), Cambridge Crystallographic Data Centre, 1 Jan 2003
DOI: 10.5517/cc6vh3m, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/cc6vh3m&sid=DataCite
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Cite this

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abstract = "The crystallization and subsequent polymorphic transformation from the β to the α form of glycine has been studied using optical microscopy, X-ray diffraction, and Fourier transform infrared spectroscopy techniques. The crystal structure and morphology of β glycine have been determined, and the influence of solvent, solubility, and process scale on its solvent-mediated transformation to the (α form was quantified. It is concluded that for the low solubility environments used in this study, the rate-determining step in the transformation process is the dissolution rate of the metastable β polymorph.",

author = "Ferrari, {Elena S.} and Davey, {Roger J.} and Cross, {Wendy I.} and Gillon, {Amy L.} and Towler, {Christopher S.}",

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AU - Ferrari, Elena S.

AU - Davey, Roger J.

AU - Cross, Wendy I.

AU - Gillon, Amy L.

AU - Towler, Christopher S.

N1 - Times Cited: 50

PY - 2003/1

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N2 - The crystallization and subsequent polymorphic transformation from the β to the α form of glycine has been studied using optical microscopy, X-ray diffraction, and Fourier transform infrared spectroscopy techniques. The crystal structure and morphology of β glycine have been determined, and the influence of solvent, solubility, and process scale on its solvent-mediated transformation to the (α form was quantified. It is concluded that for the low solubility environments used in this study, the rate-determining step in the transformation process is the dissolution rate of the metastable β polymorph.

AB - The crystallization and subsequent polymorphic transformation from the β to the α form of glycine has been studied using optical microscopy, X-ray diffraction, and Fourier transform infrared spectroscopy techniques. The crystal structure and morphology of β glycine have been determined, and the influence of solvent, solubility, and process scale on its solvent-mediated transformation to the (α form was quantified. It is concluded that for the low solubility environments used in this study, the rate-determining step in the transformation process is the dissolution rate of the metastable β polymorph.

U2 - 10.1021/cg025561b

DO - 10.1021/cg025561b

M3 - Article

SN - 1528-7483

VL - 3

SP - 53

EP - 60

JO - Crystal Growth and Design

JF - Crystal Growth and Design

IS - 1

ER -

Crystallization in polymorphic systems: The solution-mediated transformation of β to α glycine

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CCDC 204200: Experimental Crystal Structure Determination

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