TY - JOUR
T1 - CSL-independent Notch signalling: A checkpoint in cell fate decisions during development?
AU - Arias, Alfonso Martinez
AU - Zecchini, Vincent
AU - Brennan, Keith
PY - 2002/10/1
Y1 - 2002/10/1
N2 - During development, signalling by members of the Notch family of cell surface receptors plays a widespread role in the assignation of cell fates within the process of lateral inhibition. This function of Notch is mediated by a well-established mechanism that relies on a ligand-induced release of the intracellular domain of Notch (NICD) and the interaction of this fragment with members of the CSL (CBF1, Suppressor of Hairless, Lag-1) family of transcription factors within the nucleus. However, there is increasing evidence that Notch can signal in CSL-independent modes.
AB - During development, signalling by members of the Notch family of cell surface receptors plays a widespread role in the assignation of cell fates within the process of lateral inhibition. This function of Notch is mediated by a well-established mechanism that relies on a ligand-induced release of the intracellular domain of Notch (NICD) and the interaction of this fragment with members of the CSL (CBF1, Suppressor of Hairless, Lag-1) family of transcription factors within the nucleus. However, there is increasing evidence that Notch can signal in CSL-independent modes.
U2 - 10.1016/S0959-437X(02)00336-2
DO - 10.1016/S0959-437X(02)00336-2
M3 - Article
C2 - 12200157
SN - 1879-0380
VL - 12
SP - 524
EP - 533
JO - Current Opinion in Genetics and Development
JF - Current Opinion in Genetics and Development
IS - 5
ER -