Abstract
During development, signalling by members of the Notch family of cell surface receptors plays a widespread role in the assignation of cell fates within the process of lateral inhibition. This function of Notch is mediated by a well-established mechanism that relies on a ligand-induced release of the intracellular domain of Notch (NICD) and the interaction of this fragment with members of the CSL (CBF1, Suppressor of Hairless, Lag-1) family of transcription factors within the nucleus. However, there is increasing evidence that Notch can signal in CSL-independent modes.
| Original language | English |
|---|---|
| Pages (from-to) | 524-533 |
| Number of pages | 9 |
| Journal | Current Opinion in Genetics and Development |
| Volume | 12 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 1 Oct 2002 |
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