CuAAC click chemistry for the enhanced detection of novel alkyne-based natural product toxins

Edward S. Hems; Ben A. Wagstaff; Gerhard Saalbach; Robert A. Field

doi:10.1039/C8CC05113E

CuAAC click chemistry for the enhanced detection of novel alkyne-based natural product toxins

Edward S. Hems, Ben A. Wagstaff, Gerhard Saalbach, Robert A. Field

Manchester Institute of Biotechnology

Research output: Contribution to journal › Article › peer-review

Abstract

In the context of discovering and quantifying terminal alkyne-based natural products, here we report the combination of CuAAC click chemistry with LC-MS for the detection of polyether toxins (prymnesins) associated with harmful algal blooms. The added-value of the CuAAC-based approach is evident from our ability to detect novel prymnesin-like compounds in algal species with previously uncharacterised toxins.

Original language	Undefined
Journal	Chemical Communications
DOIs	https://doi.org/10.1039/C8CC05113E
Publication status	Published - 12 Oct 2018

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Manchester Institute of Biotechnology

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10.1039/C8CC05113E

Cite this

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title = "CuAAC click chemistry for the enhanced detection of novel alkyne-based natural product toxins",

abstract = "In the context of discovering and quantifying terminal alkyne-based natural products, here we report the combination of CuAAC click chemistry with LC-MS for the detection of polyether toxins (prymnesins) associated with harmful algal blooms. The added-value of the CuAAC-based approach is evident from our ability to detect novel prymnesin-like compounds in algal species with previously uncharacterised toxins.",

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AU - Saalbach, Gerhard

AU - Field, Robert A.

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AB - In the context of discovering and quantifying terminal alkyne-based natural products, here we report the combination of CuAAC click chemistry with LC-MS for the detection of polyether toxins (prymnesins) associated with harmful algal blooms. The added-value of the CuAAC-based approach is evident from our ability to detect novel prymnesin-like compounds in algal species with previously uncharacterised toxins.

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DO - 10.1039/C8CC05113E

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JO - Chemical Communications

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