Cunning factor: Macrophage migration inhibitory factor as a redox-regulated target

Alex Kudrin, David Ray

    Research output: Contribution to journalArticlepeer-review


    Macrophage migration inhibitory factor (MIF) has an amazing history of rediscoveries and controversies surroundings its true biological function. It has been classified as a powerful cytokine capable of inducing tumour necrosis factor (TNF)-α, IL-1β, IL-6, IL-8, PGE2 along with its ability to override glucocorticoid activity in relation to TNF-α release from monocytes. However, our recent study has failed to reproduce findings on MIF as a factor with cytokine-inducing properties but it has confirmed that MIF is capable of inducing glucocorticoid-counter regulating activity and amplifying LPS-driven cytokine responses. The aim of this review is to analyse the plethora of data surrounding MIF not just as a cytokine, but also as a hormone-like molecule, enzyme with atypical properties and as a thioredoxin-like protein to address fundamental questions about MIF functionality. © 2008 Australasian Society for Immunology Inc. All rights reserved.
    Original languageEnglish
    Pages (from-to)232-238
    Number of pages6
    JournalImmunology and cell biology
    Issue number3
    Publication statusPublished - Mar 2008


    • Cytokine
    • MIF
    • Oxidoreductase
    • Peroxiredoxin
    • Tautomerase
    • Thioredoxin


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