Cushing's syndrome in women with polycystic ovaries and hyperandrogenism

Neil Hanley; P. Gerry Fegan; Derek D. Sandeman; Nils Krone; Deborah Bosman; Peter J. Wood; Paul M. Stewart; Neil A. Hanley

doi:10.1038/ncpendmet0665

Cushing's syndrome in women with polycystic ovaries and hyperandrogenism

Neil Hanley, P. Gerry Fegan, Derek D. Sandeman, Nils Krone, Deborah Bosman, Peter J. Wood, Paul M. Stewart, Neil A. Hanley

Research output: Contribution to journal › Article › peer-review

Abstract

Background: A 41-year-old woman presented to an endocrinology-gynecology clinic having been diagnosed 7 years earlier with polycystic ovarian syndrome on account of hirsutism, subfertility, greasy skin, acne and multiple ovarian cysts. Ovulation induction had led to a successful pregnancy. Subfertility recurred, however, and persisted alongside a new diagnosis of hypertension and progressive weight gain. Upon examination, the patient was hypertensive with facial plethora, rounded facies and violaceous abdominal striae. Investigations: Low-dose dexamethasone test, bedtime salivary and 24-h urinary free cortisol estimations, CT scan of the abdomen, and serum hormone and gonadotropin analyses. Diagnosis: Cushing's syndrome due to a right adrenocortical adenoma. Management: The patient underwent laparoscopic right adrenalectomy, which led to resolution of all symptoms, signs and biochemical abnormalities. © 2007 Nature Publishing Group.

Original language	English
Pages (from-to)	778-783
Number of pages	5
Journal	Nature Clinical Practice Endocrinology and Metabolism
Volume	3
Issue number	11
DOIs	https://doi.org/10.1038/ncpendmet0665
Publication status	Published - Nov 2007

Keywords

Cortisol
Cushing's syndrome
Polycystic ovarian syndrome

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10.1038/ncpendmet0665

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title = "Cushing's syndrome in women with polycystic ovaries and hyperandrogenism",

abstract = "Background: A 41-year-old woman presented to an endocrinology-gynecology clinic having been diagnosed 7 years earlier with polycystic ovarian syndrome on account of hirsutism, subfertility, greasy skin, acne and multiple ovarian cysts. Ovulation induction had led to a successful pregnancy. Subfertility recurred, however, and persisted alongside a new diagnosis of hypertension and progressive weight gain. Upon examination, the patient was hypertensive with facial plethora, rounded facies and violaceous abdominal striae. Investigations: Low-dose dexamethasone test, bedtime salivary and 24-h urinary free cortisol estimations, CT scan of the abdomen, and serum hormone and gonadotropin analyses. Diagnosis: Cushing's syndrome due to a right adrenocortical adenoma. Management: The patient underwent laparoscopic right adrenalectomy, which led to resolution of all symptoms, signs and biochemical abnormalities. {\textcopyright} 2007 Nature Publishing Group.",

keywords = "Cortisol, Cushing's syndrome, Polycystic ovarian syndrome",

author = "Neil Hanley and Fegan, {P. Gerry} and Sandeman, {Derek D.} and Nils Krone and Deborah Bosman and Wood, {Peter J.} and Stewart, {Paul M.} and Hanley, {Neil A.}",

year = "2007",

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T1 - Cushing's syndrome in women with polycystic ovaries and hyperandrogenism

AU - Hanley, Neil

AU - Fegan, P. Gerry

AU - Sandeman, Derek D.

AU - Krone, Nils

AU - Bosman, Deborah

AU - Wood, Peter J.

AU - Stewart, Paul M.

AU - Hanley, Neil A.

PY - 2007/11

Y1 - 2007/11

N2 - Background: A 41-year-old woman presented to an endocrinology-gynecology clinic having been diagnosed 7 years earlier with polycystic ovarian syndrome on account of hirsutism, subfertility, greasy skin, acne and multiple ovarian cysts. Ovulation induction had led to a successful pregnancy. Subfertility recurred, however, and persisted alongside a new diagnosis of hypertension and progressive weight gain. Upon examination, the patient was hypertensive with facial plethora, rounded facies and violaceous abdominal striae. Investigations: Low-dose dexamethasone test, bedtime salivary and 24-h urinary free cortisol estimations, CT scan of the abdomen, and serum hormone and gonadotropin analyses. Diagnosis: Cushing's syndrome due to a right adrenocortical adenoma. Management: The patient underwent laparoscopic right adrenalectomy, which led to resolution of all symptoms, signs and biochemical abnormalities. © 2007 Nature Publishing Group.

AB - Background: A 41-year-old woman presented to an endocrinology-gynecology clinic having been diagnosed 7 years earlier with polycystic ovarian syndrome on account of hirsutism, subfertility, greasy skin, acne and multiple ovarian cysts. Ovulation induction had led to a successful pregnancy. Subfertility recurred, however, and persisted alongside a new diagnosis of hypertension and progressive weight gain. Upon examination, the patient was hypertensive with facial plethora, rounded facies and violaceous abdominal striae. Investigations: Low-dose dexamethasone test, bedtime salivary and 24-h urinary free cortisol estimations, CT scan of the abdomen, and serum hormone and gonadotropin analyses. Diagnosis: Cushing's syndrome due to a right adrenocortical adenoma. Management: The patient underwent laparoscopic right adrenalectomy, which led to resolution of all symptoms, signs and biochemical abnormalities. © 2007 Nature Publishing Group.

KW - Cortisol

KW - Cushing's syndrome

KW - Polycystic ovarian syndrome

U2 - 10.1038/ncpendmet0665

DO - 10.1038/ncpendmet0665

M3 - Article

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VL - 3

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EP - 783

JO - Nature Clinical Practice Endocrinology and Metabolism

JF - Nature Clinical Practice Endocrinology and Metabolism

IS - 11

ER -

Cushing's syndrome in women with polycystic ovaries and hyperandrogenism

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Keywords

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