TY - JOUR
T1 - Cutting edge: Polarized Th cell response induction by transferred antigen-pulsed dendritic cells is dependent on IL-4 or IL-12 production by recipient cells
AU - MacDonald, Andrew S.
AU - Pearce, Edward J.
N1 - A132573, PHS HHS, United StatesN01-AI-55270, NIAID NIH HHS, United States
PY - 2002/4/1
Y1 - 2002/4/1
N2 - To assess the influence of dendritic cell (DC) production of polarizing cytokines on Th2 and Th1 development we transferred Ag-pulsed DC generated from wild-type, IL-4-/-, or IL-12-/- mice into wild-type, IL-4-/-, or IL-12-/- recipients. We found that DC IL-4 was not necessary for Th2 induction and that, surprisingly, DC IL-12 was not an absolute requirement for Th1 development. However, DC IL-12 production facilitated optimal Th1 response development. Critically, recipient ability to produce IL-4 or IL-12 was essential for either Th2 or Th1 development. These data help delineate the source and importance of IL-4 and IL-12 in the process of induction of polarized T cell responses by DC.
AB - To assess the influence of dendritic cell (DC) production of polarizing cytokines on Th2 and Th1 development we transferred Ag-pulsed DC generated from wild-type, IL-4-/-, or IL-12-/- mice into wild-type, IL-4-/-, or IL-12-/- recipients. We found that DC IL-4 was not necessary for Th2 induction and that, surprisingly, DC IL-12 was not an absolute requirement for Th1 development. However, DC IL-12 production facilitated optimal Th1 response development. Critically, recipient ability to produce IL-4 or IL-12 was essential for either Th2 or Th1 development. These data help delineate the source and importance of IL-4 and IL-12 in the process of induction of polarized T cell responses by DC.
M3 - Article
C2 - 11907061
SN - 1550-6606
VL - 168
SP - 3127
EP - 3130
JO - Journal of Immunology
JF - Journal of Immunology
IS - 7
ER -