Cyclic hypoxia does not alter RAD51 expression or PARP inhibitor cell kill in tumor cells

Ramya Kumareswaran; Naz Chaudary; Karolina Jaluba; Alice Meng; Jenna Sykes; Asm Borhan; Richard P. Hill; Robert G. Bristow

doi:10.1016/j.radonc.2015.03.027

Cyclic hypoxia does not alter RAD51 expression or PARP inhibitor cell kill in tumor cells

Ramya Kumareswaran, Naz Chaudary, Karolina Jaluba, Alice Meng, Jenna Sykes, Asm Borhan, Richard P. Hill, Robert G. Bristow

Division of Cancer Sciences (L5)

Research output: Contribution to journal › Article › peer-review

Abstract

Solid tumors contain regions of chronic and cyclic hypoxia. Chronic hypoxia can downregulate RAD51 and sensitize cells to PARP inhibition. Herein, we show that RAD51 expression, cell survival and toxicity to PARP inhibition is not affected under cyclic hypoxic conditions. This suggests that PARP inhibition may be selectively toxic in tumor sub-regions associated with chronic hypoxia.

Original language	English
Pages (from-to)	388-391
Number of pages	4
Journal	Radiotherapy and Oncology
Volume	116
Issue number	3
DOIs	https://doi.org/10.1016/j.radonc.2015.03.027
Publication status	Published - 1 Sept 2015

Keywords

Cyclic hypoxia
DNA repair
PARP inhibition
RAD51

Research Beacons, Institutes and Platforms

Manchester Cancer Research Centre

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.radonc.2015.03.027

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title = "Cyclic hypoxia does not alter RAD51 expression or PARP inhibitor cell kill in tumor cells",

abstract = "Solid tumors contain regions of chronic and cyclic hypoxia. Chronic hypoxia can downregulate RAD51 and sensitize cells to PARP inhibition. Herein, we show that RAD51 expression, cell survival and toxicity to PARP inhibition is not affected under cyclic hypoxic conditions. This suggests that PARP inhibition may be selectively toxic in tumor sub-regions associated with chronic hypoxia.",

keywords = "Cyclic hypoxia, DNA repair, PARP inhibition, RAD51",

author = "Ramya Kumareswaran and Naz Chaudary and Karolina Jaluba and Alice Meng and Jenna Sykes and Asm Borhan and Hill, {Richard P.} and Bristow, {Robert G.}",

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T1 - Cyclic hypoxia does not alter RAD51 expression or PARP inhibitor cell kill in tumor cells

AU - Kumareswaran, Ramya

AU - Chaudary, Naz

AU - Jaluba, Karolina

AU - Meng, Alice

AU - Sykes, Jenna

AU - Borhan, Asm

AU - Hill, Richard P.

AU - Bristow, Robert G.

PY - 2015/9/1

Y1 - 2015/9/1

N2 - Solid tumors contain regions of chronic and cyclic hypoxia. Chronic hypoxia can downregulate RAD51 and sensitize cells to PARP inhibition. Herein, we show that RAD51 expression, cell survival and toxicity to PARP inhibition is not affected under cyclic hypoxic conditions. This suggests that PARP inhibition may be selectively toxic in tumor sub-regions associated with chronic hypoxia.

AB - Solid tumors contain regions of chronic and cyclic hypoxia. Chronic hypoxia can downregulate RAD51 and sensitize cells to PARP inhibition. Herein, we show that RAD51 expression, cell survival and toxicity to PARP inhibition is not affected under cyclic hypoxic conditions. This suggests that PARP inhibition may be selectively toxic in tumor sub-regions associated with chronic hypoxia.

KW - Cyclic hypoxia

KW - DNA repair

KW - PARP inhibition

KW - RAD51

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U2 - 10.1016/j.radonc.2015.03.027

DO - 10.1016/j.radonc.2015.03.027

M3 - Article

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AN - SCOPUS:84944175966

SN - 0167-8140

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SP - 388

EP - 391

JO - Radiotherapy and Oncology

JF - Radiotherapy and Oncology

IS - 3

ER -

Cyclic hypoxia does not alter RAD51 expression or PARP inhibitor cell kill in tumor cells

Abstract

Keywords

Research Beacons, Institutes and Platforms

UN SDGs

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