Cyclin E overexpression reduces infiltrative growth in breast cancer: Yet another link between proliferation control and tumor invasion

Goran Landberg, Pontus Berglund, Göran Landberg

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Overexpression of cyclin E is strongly linked to an aggressive phenotype and poor prognosis in breast cancer. Unexpectedly, it has been shown that cyclin E overexpression decreases mobility and invasiveness of breast cancer cells. In fact, in a study of 985 breast cancers, cyclin E correlated with less infiltrative growth. This suggests a novel function for cyclin E in breast cancer tumorigenesis and a mutual control of proliferation and invasive behavior. ©2006 Landes Bioscience.
    Original languageEnglish
    Pages (from-to)606-609
    Number of pages3
    JournalCell Cycle
    Volume5
    Issue number6
    DOIs
    Publication statusPublished - 16 Mar 2006

    Keywords

    • Breast cancer
    • Cyclin E
    • Invasion
    • Medullary breast cancer
    • Microarray
    • Proliferation

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