Cytokine blocking agents in dermatology

Jason D L Williams, C. E M Griffiths

    Research output: Contribution to journalArticlepeer-review


    Cytokines are intercellular messengers that have an important role in the development and maintenance of cutaneous inflammation. The primacy of cytokines in eliciting cutaneous immune responses makes them a highly attractive target for new biological response modifiers. Targeting of cytokines is still in its infancy for therapy of skin disease. However, blocking tumour necrosis factor α by infliximab or etanercept has shown particular promise, especially in the management of psoriasis. Anecdotally, this approach is also effective for a variety of dermatological conditions including pyoderma gangrenosum and Behçet's syndrome. We review the current and prospective roles of cytokine blocking agents in the treatment of skin disease.
    Original languageEnglish
    Pages (from-to)585-590
    Number of pages5
    JournalClinical and Experimental Dermatology
    Issue number7
    Publication statusPublished - 2002


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