Cytokine gene polymorphism and heart transplant rejection

David Turner; Simon C D Grant; Nizar Yonan; Stephen Sheldon; Philip A. Dyer; Paul J. Sinnott; Ian V. Hutchinson

doi:10.1097/00007890-199709150-00021

Cytokine gene polymorphism and heart transplant rejection

David Turner, Simon C D Grant, Nizar Yonan, Stephen Sheldon, Philip A. Dyer, Paul J. Sinnott, Ian V. Hutchinson

Research output: Contribution to journal › Article › peer-review

Abstract

Background. Allograft rejection is mediated by cytokines. As polymorphism in cytokine genes can result in interindividual differences in cytokine production, we hypothesize that some patients may have an increased risk of rejection. Methods. We have related polymorphisms that influence cytokine production in the tumor necrosis factor (TNF)-A and interleukin (IL)-10 genes to early graft rejection in 115 heart transplant recipients. Results. Certain combinations of TNF-A and IL-10 gene polymorphisms are associated with rejection. Five of 19 patients who had high levels of rejection typed as high TNF-α/low IL-10 producers compared with 4 of 96 patients with lower levels of rejection (P

Original language	English
Pages (from-to)	776-779
Number of pages	3
Journal	Transplantation
Volume	64
Issue number	5
DOIs	https://doi.org/10.1097/00007890-199709150-00021
Publication status	Published - 15 Sept 1997

Keywords

genetics: Cytokines
Genetic Predisposition to Disease
Genotype
genetics: Graft Rejection
immunology: Heart Transplantation
Humans
genetics: Interleukin-10
Polymorphism, Genetic
genetics: Tumor Necrosis Factor-alpha

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1097/00007890-199709150-00021

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title = "Cytokine gene polymorphism and heart transplant rejection",

abstract = "Background. Allograft rejection is mediated by cytokines. As polymorphism in cytokine genes can result in interindividual differences in cytokine production, we hypothesize that some patients may have an increased risk of rejection. Methods. We have related polymorphisms that influence cytokine production in the tumor necrosis factor (TNF)-A and interleukin (IL)-10 genes to early graft rejection in 115 heart transplant recipients. Results. Certain combinations of TNF-A and IL-10 gene polymorphisms are associated with rejection. Five of 19 patients who had high levels of rejection typed as high TNF-α/low IL-10 producers compared with 4 of 96 patients with lower levels of rejection (P",

keywords = "genetics: Cytokines, Genetic Predisposition to Disease, Genotype, genetics: Graft Rejection, immunology: Heart Transplantation, Humans, genetics: Interleukin-10, Polymorphism, Genetic, genetics: Tumor Necrosis Factor-alpha",

author = "David Turner and Grant, {Simon C D} and Nizar Yonan and Stephen Sheldon and Dyer, {Philip A.} and Sinnott, {Paul J.} and Hutchinson, {Ian V.}",

year = "1997",

month = sep,

day = "15",

doi = "10.1097/00007890-199709150-00021",

language = "English",

volume = "64",

pages = "776--779",

journal = "Transplantation",

issn = "1534-6080",

publisher = "Lippincott Williams & Wilkins",

number = "5",

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TY - JOUR

T1 - Cytokine gene polymorphism and heart transplant rejection

AU - Turner, David

AU - Grant, Simon C D

AU - Yonan, Nizar

AU - Sheldon, Stephen

AU - Dyer, Philip A.

AU - Sinnott, Paul J.

AU - Hutchinson, Ian V.

PY - 1997/9/15

Y1 - 1997/9/15

N2 - Background. Allograft rejection is mediated by cytokines. As polymorphism in cytokine genes can result in interindividual differences in cytokine production, we hypothesize that some patients may have an increased risk of rejection. Methods. We have related polymorphisms that influence cytokine production in the tumor necrosis factor (TNF)-A and interleukin (IL)-10 genes to early graft rejection in 115 heart transplant recipients. Results. Certain combinations of TNF-A and IL-10 gene polymorphisms are associated with rejection. Five of 19 patients who had high levels of rejection typed as high TNF-α/low IL-10 producers compared with 4 of 96 patients with lower levels of rejection (P

AB - Background. Allograft rejection is mediated by cytokines. As polymorphism in cytokine genes can result in interindividual differences in cytokine production, we hypothesize that some patients may have an increased risk of rejection. Methods. We have related polymorphisms that influence cytokine production in the tumor necrosis factor (TNF)-A and interleukin (IL)-10 genes to early graft rejection in 115 heart transplant recipients. Results. Certain combinations of TNF-A and IL-10 gene polymorphisms are associated with rejection. Five of 19 patients who had high levels of rejection typed as high TNF-α/low IL-10 producers compared with 4 of 96 patients with lower levels of rejection (P

KW - genetics: Cytokines

KW - Genetic Predisposition to Disease

KW - Genotype

KW - genetics: Graft Rejection

KW - immunology: Heart Transplantation

KW - Humans

KW - genetics: Interleukin-10

KW - Polymorphism, Genetic

KW - genetics: Tumor Necrosis Factor-alpha

U2 - 10.1097/00007890-199709150-00021

DO - 10.1097/00007890-199709150-00021

M3 - Article

SN - 1534-6080

VL - 64

SP - 776

EP - 779

JO - Transplantation

JF - Transplantation

IS - 5

ER -

Cytokine gene polymorphism and heart transplant rejection

Abstract

Keywords

UN SDGs

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