Cytomegalovirus is present in a very high proportion of brains from vascular dementia patients

Woan R. Lin; Matthew A. Wozniak; Gordon K. Wilcock; Ruth F. Itzhaki

doi:10.1006/nbdi.2001.0465

Cytomegalovirus is present in a very high proportion of brains from vascular dementia patients

Woan R. Lin, Matthew A. Wozniak, Gordon K. Wilcock, Ruth F. Itzhaki

Research output: Contribution to journal › Article › peer-review

Abstract

We previously found that herpes simplex type 1 virus (HSV1), when present in brain of carriers of the apolipoprotein E type 4 allele is a strong risk factor for Alzheimer's disease. To find if HSV1 or certain other herpesviruses are involved in vascular dementia (VaD), we searched post mortem brain specimens from patients suffering from VaD for the presence of HSVl, cytomegalovirus (CMV), and human herpesvirus type 6 DNA, using polymerase chain reaction. We have found that a very high proportion of the VaD patients, 93% (14/15), but not of age-matched normals, 34% (10/29), harbor CMV DNA (P = 0.0002); the proportions of the patients harboring the other viruses in brain do not differ significantly from those of the normals. Further studies are needed to reveal whether or not the association of CMV with VaD is causal. © 2002 Elsevier Science (USA).

Original language	English
Pages (from-to)	82-87
Number of pages	5
Journal	Neurobiology of disease
Volume	9
Issue number	1
DOIs	https://doi.org/10.1006/nbdi.2001.0465
Publication status	Published - 2002

Keywords

Brain
Cytomegalovirus
Herpes simplex virus type 1
Human herpesvirus 6
Polymerase chain reaction
Vascular dementia

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10.1006/nbdi.2001.0465

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title = "Cytomegalovirus is present in a very high proportion of brains from vascular dementia patients",

abstract = "We previously found that herpes simplex type 1 virus (HSV1), when present in brain of carriers of the apolipoprotein E type 4 allele is a strong risk factor for Alzheimer's disease. To find if HSV1 or certain other herpesviruses are involved in vascular dementia (VaD), we searched post mortem brain specimens from patients suffering from VaD for the presence of HSVl, cytomegalovirus (CMV), and human herpesvirus type 6 DNA, using polymerase chain reaction. We have found that a very high proportion of the VaD patients, 93% (14/15), but not of age-matched normals, 34% (10/29), harbor CMV DNA (P = 0.0002); the proportions of the patients harboring the other viruses in brain do not differ significantly from those of the normals. Further studies are needed to reveal whether or not the association of CMV with VaD is causal. {\textcopyright} 2002 Elsevier Science (USA).",

keywords = "Brain, Cytomegalovirus, Herpes simplex virus type 1, Human herpesvirus 6, Polymerase chain reaction, Vascular dementia",

author = "Lin, {Woan R.} and Wozniak, {Matthew A.} and Wilcock, {Gordon K.} and Itzhaki, {Ruth F.}",

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T1 - Cytomegalovirus is present in a very high proportion of brains from vascular dementia patients

AU - Lin, Woan R.

AU - Wozniak, Matthew A.

AU - Wilcock, Gordon K.

AU - Itzhaki, Ruth F.

PY - 2002

Y1 - 2002

N2 - We previously found that herpes simplex type 1 virus (HSV1), when present in brain of carriers of the apolipoprotein E type 4 allele is a strong risk factor for Alzheimer's disease. To find if HSV1 or certain other herpesviruses are involved in vascular dementia (VaD), we searched post mortem brain specimens from patients suffering from VaD for the presence of HSVl, cytomegalovirus (CMV), and human herpesvirus type 6 DNA, using polymerase chain reaction. We have found that a very high proportion of the VaD patients, 93% (14/15), but not of age-matched normals, 34% (10/29), harbor CMV DNA (P = 0.0002); the proportions of the patients harboring the other viruses in brain do not differ significantly from those of the normals. Further studies are needed to reveal whether or not the association of CMV with VaD is causal. © 2002 Elsevier Science (USA).

AB - We previously found that herpes simplex type 1 virus (HSV1), when present in brain of carriers of the apolipoprotein E type 4 allele is a strong risk factor for Alzheimer's disease. To find if HSV1 or certain other herpesviruses are involved in vascular dementia (VaD), we searched post mortem brain specimens from patients suffering from VaD for the presence of HSVl, cytomegalovirus (CMV), and human herpesvirus type 6 DNA, using polymerase chain reaction. We have found that a very high proportion of the VaD patients, 93% (14/15), but not of age-matched normals, 34% (10/29), harbor CMV DNA (P = 0.0002); the proportions of the patients harboring the other viruses in brain do not differ significantly from those of the normals. Further studies are needed to reveal whether or not the association of CMV with VaD is causal. © 2002 Elsevier Science (USA).

KW - Brain

KW - Cytomegalovirus

KW - Herpes simplex virus type 1

KW - Human herpesvirus 6

KW - Polymerase chain reaction

KW - Vascular dementia

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JF - Neurobiology of disease

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Cytomegalovirus is present in a very high proportion of brains from vascular dementia patients

Abstract

Keywords

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