Cytotoxic Michael-type amine adducts of α-methylene lactones alantolactone and isoalantolactone

Nicholas J. Lawrence, Alan T. McGown, Jane Nduka, John A. Hadfield, Robin G. Pritchard

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Two series of cytotoxic (IC50, K562 cell line, 1-24 μM) α-aminomethyl substituted lactones 3 and 4 were prepared by stereoselective Michael-type addition of amines to alantolactone (1) and isoalantolactone (2). The lactones 1 and 2 and their amine adducts induce apoptosis and act as alkylating agents. © 2001 Elsevier Science Ltd.
    Original languageEnglish
    Pages (from-to)429-431
    Number of pages2
    JournalBioorganic and Medicinal Chemistry Letters
    Volume11
    Issue number3
    DOIs
    Publication statusPublished - 12 Feb 2001

    Keywords

    • Cytotoxic agents (prepn. and cytotoxic activity of Michael-type amine adducts of alantolactone and isoalantolactone); Amines Role: RCT (Reactant), RACT (Reactant or reagent) (prepn. and cytotoxic activity of Michael-type amine adducts of alantolactone and isoalantolactone); Crystal structure; Molecular structure (prepn. and properties of Michael-type amine adduct of isoalantolactone); Michael reaction (stereoselective; prepn. and cytotoxic activity of Michael-type amine adducts of alantolactone and isoalantolactone)

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