Cytotoxic Michael-type amine adducts of α-methylene lactones alantolactone and isoalantolactone

Nicholas J. Lawrence; Alan T. McGown; Jane Nduka; John A. Hadfield; Robin G. Pritchard

doi:10.1016/S0960-894X(00)00686-7

Cytotoxic Michael-type amine adducts of α-methylene lactones alantolactone and isoalantolactone

Nicholas J. Lawrence
, Alan T. McGown
, Jane Nduka
, John A. Hadfield
, Robin G. Pritchard

Research output: Contribution to journal › Article › peer-review

Abstract

Two series of cytotoxic (IC50, K562 cell line, 1-24 μM) α-aminomethyl substituted lactones 3 and 4 were prepared by stereoselective Michael-type addition of amines to alantolactone (1) and isoalantolactone (2). The lactones 1 and 2 and their amine adducts induce apoptosis and act as alkylating agents. © 2001 Elsevier Science Ltd.

Original language	English
Pages (from-to)	429-431
Number of pages	2
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	11
Issue number	3
DOIs	https://doi.org/10.1016/S0960-894X(00)00686-7
Publication status	Published - 12 Feb 2001

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Cytotoxic agents (prepn. and cytotoxic activity of Michael-type amine adducts of alantolactone and isoalantolactone); Amines Role: RCT (Reactant), RACT (Reactant or reagent) (prepn. and cytotoxic activity of Michael-type amine adducts of alantolactone and isoalantolactone); Crystal structure; Molecular structure (prepn. and properties of Michael-type amine adduct of isoalantolactone); Michael reaction (stereoselective; prepn. and cytotoxic activity of Michael-type amine adducts of alantolactone and isoalantolactone)

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10.1016/S0960-894X(00)00686-7

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title = "Cytotoxic Michael-type amine adducts of α-methylene lactones alantolactone and isoalantolactone",

abstract = "Two series of cytotoxic (IC50, K562 cell line, 1-24 μM) α-aminomethyl substituted lactones 3 and 4 were prepared by stereoselective Michael-type addition of amines to alantolactone (1) and isoalantolactone (2). The lactones 1 and 2 and their amine adducts induce apoptosis and act as alkylating agents. {\textcopyright} 2001 Elsevier Science Ltd.",

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author = "Lawrence, \{Nicholas J.\} and McGown, \{Alan T.\} and Jane Nduka and Hadfield, \{John A.\} and Pritchard, \{Robin G.\}",

year = "2001",

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doi = "10.1016/S0960-894X(00)00686-7",

language = "English",

volume = "11",

pages = "429--431",

journal = "Bioorganic and Medicinal Chemistry Letters",

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TY - JOUR

T1 - Cytotoxic Michael-type amine adducts of α-methylene lactones alantolactone and isoalantolactone

AU - Lawrence, Nicholas J.

AU - McGown, Alan T.

AU - Nduka, Jane

AU - Hadfield, John A.

AU - Pritchard, Robin G.

PY - 2001/2/12

Y1 - 2001/2/12

N2 - Two series of cytotoxic (IC50, K562 cell line, 1-24 μM) α-aminomethyl substituted lactones 3 and 4 were prepared by stereoselective Michael-type addition of amines to alantolactone (1) and isoalantolactone (2). The lactones 1 and 2 and their amine adducts induce apoptosis and act as alkylating agents. © 2001 Elsevier Science Ltd.

AB - Two series of cytotoxic (IC50, K562 cell line, 1-24 μM) α-aminomethyl substituted lactones 3 and 4 were prepared by stereoselective Michael-type addition of amines to alantolactone (1) and isoalantolactone (2). The lactones 1 and 2 and their amine adducts induce apoptosis and act as alkylating agents. © 2001 Elsevier Science Ltd.

KW - Cytotoxic agents (prepn. and cytotoxic activity of Michael-type amine adducts of alantolactone and isoalantolactone); Amines Role: RCT (Reactant), RACT (Reactant or reagent) (prepn. and cytotoxic activity of Michael-type amine adducts of alantolactone and

U2 - 10.1016/S0960-894X(00)00686-7

DO - 10.1016/S0960-894X(00)00686-7

M3 - Article

SN - 1464-3405

VL - 11

SP - 429

EP - 431

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 3

ER -

Cytotoxic Michael-type amine adducts of α-methylene lactones alantolactone and isoalantolactone

Abstract

UN SDGs

Keywords

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