D-mannitol in cerebrospinal fluid of patients with AIDS and cryptococcal meningitis

Garry M. Megson, David A. Stevens, John R. Hamilton, David W. Denning

Research output: Contribution to journalArticlepeer-review


Cryptococcal meningitis (CM) is associated with raised intracranial pressure which is linked with serious neurological sequelae. Cryptococcus neoformans produces D-mannitol in vitro and in experimental meningitis in rabbits. Mannitol present in the cerebrospinal fluid (CSF) of CM patients could exacerbate raised intracranial pressure and contribute to neurological damage. To link CSF mannitol to cryptococcal infection, levels of mannitol in the CSF of AIDS patients with CM were measured by gas-liquid chromatography. Mannitol was detected in 19 of 21 samples (range, 1.5 to 26.2 nig/liter), but there was no quantitative correlation between the mannitol concentration and the cryptococcal antigen titer.

Original languageEnglish
Pages (from-to)218-221
Number of pages4
JournalJournal of clinical microbiology
Issue number1
Publication statusPublished - 1 Dec 1996


  • AIDS related complex
  • animal experiment
  • article
  • cerebrospinal fluid analysis
  • clinical feature
  • drug determination


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